TY - JOUR
T1 - COVID-19 in hospitalized lung and non-lung solid organ transplant recipients
T2 - A comparative analysis from a multicenter study
AU - the UW COVID-19 SOT Study Team
AU - Heldman, Madeleine R.
AU - Kates, Olivia S.
AU - Safa, Kassem
AU - Kotton, Camille N.
AU - Georgia, Sarah J.
AU - Steinbrink, Julie M.
AU - Alexander, Barbara D.
AU - Hemmersbach-Miller, Marion
AU - Blumberg, Emily A.
AU - Crespo, Maria M.
AU - Multani, Ashrit
AU - Lewis, Angelica V.
AU - Eugene Beaird, Omer
AU - Haydel, Brandy
AU - La Hoz, Ricardo M.
AU - Moni, Lisset
AU - Condor, Yesabeli
AU - Flores, Sandra
AU - Munoz, Carlos G.
AU - Guitierrez, Juan
AU - Diaz, Esther I.
AU - Diaz, Daniela
AU - Vianna, Rodrigo
AU - Guerra, Giselle
AU - Loebe, Matthias
AU - Rakita, Robert M.
AU - Malinis, Maricar
AU - Azar, Marwan M.
AU - Hemmige, Vagish
AU - McCort, Margaret E.
AU - Chaudhry, Zohra S.
AU - Singh, Pooja
AU - Hughes, Kailey
AU - Velioglu, Arzu
AU - Yabu, Julie M.
AU - Morillis, Jose A.
AU - Mehta, Sapna A.
AU - Tanna, Sajal D.
AU - Ison, Michael G.
AU - Tomic, Rade
AU - Candace Derenge, Ariella
AU - van Duin, David
AU - Maximin, Adrienne
AU - Gilbert, Carlene
AU - Goldman, Jason D.
AU - Sehgal, Sameep
AU - Weisshaar, Dana
AU - Girgis, Reda E.
AU - Nelson, Joanna
AU - Lease, Erika D.
N1 - Funding Information:
The following are the members of the UW COVID‐19 SOT Study Team, without whom this work would not have been possible: Cameron Lawrence BS, William Bennett MD, Jennifer Leandro, Afrah Sait MD, Amy Rumore PharmD, Patricia West PhD, Amy Jeng MD, Valida Bajrovic MD, Erin P Bilgili BS, Tracy Anderson‐Haag, PharmD, BCPS, Abigail Nastase, Abbas Badami MD, Jesus Alvarez‐Garcia MD, Lyndsey Bowman‐Anger PharmD, Lovelyn Julien MPH, Carlos Ortiz‐Bautista MD, Rachel Friedman‐Morocco MD, Kiran Gajurel MD, Lizbeth Cahuayme‐Zuniga MD, Mark Wakefield MD, Monica Fung MD, Nicole Theodoropoulos MD MS, Sally T Chuang MD, Srividya Bhandaram MD, Massimiliano Veroux MD PhD, Bhavna Chopra MD, Diana Florescu MD, Danielle Witteck, Daniela Diaz, Kathryn Ripley NP‐C, Kapil Saharia MD MPH, Sanjeev Akkina MD, Todd P. McCarty MD, Ally Webb PharmD, Akanksha Arya MD, Giridhar Vedula MD, Jose‐Marie El‐Amm MD, M. Katherine Dokus, Arun Narayanan MD, Priscila Cilene Leon Bueno de Camargo MD, Rosemary Ouseph MD, Andrew Breuckner PharmD, Alfred Luk MD, Avinash Aujayeb MBBS MRCP, Daniel Ganger MD, Douglas S. Keith MD, Federica Meloni MD, Ghady Haidar MD, Lori Zapernick, Megan Moraels MD, Nitender Goyal MD, Tanvi Sharma MD MPH, Uma Malhotra MD, Alexander Kuo MD, Ana P Rossi MD MPH, Angelina Edwards MD, Brian Keller MD PhD, Christy Beneri DO, Darby Derringer PharmD, Edward Dominguez MD, Elise Carlson PharmD, Faris Hashim MD, Haris Murad MD, Heinrike Wilkens MD, Henry Neumann MD, Imran Gani MD, Joseph Kahwaji MD, Joyce Popoola FRCP, Marian Michaels MD MPH, Niyati Jakharia MD, Oveimar De la Cruz MD, Alfredo Puing MD, Reza Motallebzadeh, Ravi Velagapudi MD, Rajan Kapoor MD, Sridhar Allam MD, Fernanda Silveira MD MD, Surabhi Vora MD MPH, Ursala M Kelly MD, Uttam Reddy MD, Vikas Dharnidharka MD MPH, Hani Wadei MD, and Lominadze Zurabi MD. This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (T32AI118690 to M.R.H. and O.S.K.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
The following are the members of the UW COVID-19 SOT Study Team, without whom this work would not have been possible: Cameron Lawrence BS, William Bennett MD, Jennifer Leandro, Afrah Sait MD, Amy Rumore PharmD, Patricia West PhD, Amy Jeng MD, Valida Bajrovic MD, Erin P Bilgili BS, Tracy Anderson-Haag, PharmD, BCPS, Abigail Nastase, Abbas Badami MD, Jesus Alvarez-Garcia MD, Lyndsey Bowman-Anger PharmD, Lovelyn Julien MPH, Carlos Ortiz-Bautista MD, Rachel Friedman-Morocco MD, Kiran Gajurel MD, Lizbeth Cahuayme-Zuniga MD, Mark Wakefield MD, Monica Fung MD, Nicole Theodoropoulos MD MS, Sally T Chuang MD, Srividya Bhandaram MD, Massimiliano Veroux MD PhD, Bhavna Chopra MD, Diana Florescu MD, Danielle Witteck, Daniela Diaz, Kathryn Ripley NP-C, Kapil Saharia MD MPH, Sanjeev Akkina MD, Todd P. McCarty MD, Ally Webb PharmD, Akanksha Arya MD, Giridhar Vedula MD, Jose-Marie El-Amm MD, M. Katherine Dokus, Arun Narayanan MD, Priscila Cilene Leon Bueno de Camargo MD, Rosemary Ouseph MD, Andrew Breuckner PharmD, Alfred Luk MD, Avinash Aujayeb MBBS MRCP, Daniel Ganger MD, Douglas S. Keith MD, Federica Meloni MD, Ghady Haidar MD, Lori Zapernick, Megan Moraels MD, Nitender Goyal MD, Tanvi Sharma MD MPH, Uma Malhotra MD, Alexander Kuo MD, Ana P Rossi MD MPH, Angelina Edwards MD, Brian Keller MD PhD, Christy Beneri DO, Darby Derringer PharmD, Edward Dominguez MD, Elise Carlson PharmD, Faris Hashim MD, Haris Murad MD, Heinrike Wilkens MD, Henry Neumann MD, Imran Gani MD, Joseph Kahwaji MD, Joyce Popoola FRCP, Marian Michaels MD MPH, Niyati Jakharia MD, Oveimar De la Cruz MD, Alfredo Puing MD, Reza Motallebzadeh, Ravi Velagapudi MD, Rajan Kapoor MD, Sridhar Allam MD, Fernanda Silveira MD MD, Surabhi Vora MD MPH, Ursala M Kelly MD, Uttam Reddy MD, Vikas Dharnidharka MD MPH, Hani Wadei MD, and Lominadze Zurabi MD. This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (T32AI118690 to M.R.H. and O.S.K.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2021/8
Y1 - 2021/8
N2 - Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p =.02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p =.032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0–2.6, p =.04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0–11.3, p =.05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
AB - Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p =.02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p =.032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0–2.6, p =.04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0–11.3, p =.05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
KW - clinical research/practice
KW - infection and infectious agents - viral
KW - infectious disease
KW - lung (allograft) function/dysfunction
KW - lung disease: infectious
KW - lung transplantation/pulmonology
KW - organ transplantation in general
UR - http://www.scopus.com/inward/record.url?scp=85110355028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110355028&partnerID=8YFLogxK
U2 - 10.1111/ajt.16692
DO - 10.1111/ajt.16692
M3 - Article
C2 - 34008917
AN - SCOPUS:85110355028
SN - 1600-6135
VL - 21
SP - 2774
EP - 2784
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 8
ER -