Corrigendum to High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype12 (Translational Oncology (2019) 12(2) (256–268), (S193652331830439X), (10.1016/j.tranon.2018.10.010))

The authors regret <insert corrigendum text>. The authors would like to apologize for any inconvenience caused. The authors regret that an error in Figure S1 of the manuscript has been identified. Some images in Figure 1 were duplicated within Figure S1; hence, this corrigendum addresses this error. Following changes were made to improve the quality of the results section: To further address the contribution of KRT8 and KRT18 with respect to liver pathology in livers of wild-type (wt), Krt8^+/−, Krt8^−/−, Krt18^{+/ −}, and Krt18^−/− mice aged 3 and 17-20 months, we performed, in addition to light microscopy, double immunofluorescence microscopy (DIF) using antibodies against K8/18 and p62. Moreover, heptameric oligothiophene, h-HTAA (Mahajan et al., 2011), was used to confirm ß-sheet conformation (Figure 1). In livers of 6-month-old Krt18^+/− and Krt18^−/− mice, total FA amounts were significantly increased compared to wt mice (Figure 2, Figure S1, and Table S1). The following NAFLD-related mRNAs remained largely unchanged: Malonyl-CoA decarboxylase (Mlycd), Microsomal triglyceride transfer protein (Mttp), ATP-binding cassette, sub-family C, member 2 (Cftr/Mrp) (Figure S2A), Insulin receptor substrate 1 (Isr1), Glutamate-cysteine ligase, modifier subunit (Gclm), Fatty acid synthase (Fasn) (Figure S2B), Diacylglycerol O-acyltransferase 2 (Dgat2), Angiotensin II receptor 1a (Agtr1α), Adiponectin receptor 2 (Adipor2) (Figure S2C) and Peroxisome proliferator activated receptor alpha (Pparα) (Figure S2D). In addition, the following changes have been made in the discussion section qRT-PCR analyses revealed a significant increase of Srebpb1 mRNA level in Krt18^−/− mice aged 3 and 6 months, whereas no increased mRNA expression of Pparα was identified (Figure 3; Figure S2).