Correspondence: The association between morphea profunda and monoclonal gammopathy: A case series

Justin Endo, Nicole Strickland, Simer Grewal, Travis Vandergriff, Thomas Keenan, B. Jack Longley, Heidi Jacobe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


It is known that eosinophilic fasciitis can be associated with monoclonal gammopathy. There is clinical similarity between eosinophilic fasciitis and morphea profunda, but it is unclear whether morphea profunda might be associated with monoclonal gammopathy. The temporal quantification of gammopathy in morphea profunda has not been well characterized. We describe four patients with morphea profunda that were associated with monoclonal gammopathy. Three were associated with monoclonal IgG protein and one with IgM. No patients in our series developed myeloma. In conclusion, the association of monoclonal gammopathy is not unique to eosinophilic fasciitis and scleromyxedema. Further studies are necessary to characterize further the relationship between the two conditions.

Original languageEnglish (US)
JournalDermatology Online Journal
Issue number3
StatePublished - Mar 1 2016


  • Eosinophilic fasciitis
  • Fibrosing disorder
  • Gammaglobulinemia
  • Gammopathy
  • M-spike
  • MGUS
  • Monoclonal gammopathy of unknown significance
  • Morphea
  • Plasma cell dyscrasia

ASJC Scopus subject areas

  • Dermatology


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