@article{f0ac0fbaf31046669bb15696ee8abd96,
title = "Correspondence between Resting-State Activity and Brain Gene Expression",
abstract = "The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations between gene expression in the brain and functional activity by comparing fractional amplitude of low-frequency fluctuations (fALFF) from two independent human fMRI resting-state datasets to regional cortical gene expression from a newly generated RNA-seq dataset and two additional gene expression datasets to obtain robust and reproducible correlations. We find significantly more genes correlated with fALFF than expected by chance and identify specific genes correlated with the imaging signals in multiple expression datasets in the default mode network. Together, these data support a population-level relationship between regional steady-state brain gene expression and resting-state brain activity.",
author = "Wang, {Guang Zhong} and Belgard, {T. Grant} and Deng Mao and Leslie Chen and Stefano Berto and Preuss, {Todd M.} and Hanzhang Lu and Geschwind, {Daniel H.} and Genevieve Konopka",
note = "Funding Information: We thank Neelroop Parikshak for helpful discussions and providing custom code. This work was supported by NIH grants (T32NS048004, T.G.B.; R00MH090238, R01MH102603, R21MH107672, G.K.; R01MH103517, T.M.P. and G.K.; R37MH060233, R01MH094714, R01MH100027, D.H.G), a March of Dimes Basil O{\textquoteright}Connor Award (5-FY13-199), Once Upon a Time Foundation, Friends of the Alzheimer{\textquoteright}s Disease Center at UTSW, CREW Dallas and a Jon Heighten Scholar in Autism Research Award to G.K., the Yerkes National Primate Research Center (National Center for Research Resources P51RR165; currently Office of Research Infrastructure Programs/OD P51OD11132) to T.M.P.; the Simons Foundation (SFARI 206744) to D.H.G. Human tissue was obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland (NICHD contract numbers N01-HD-4-3368 and N01-HD-4-3383). The role of the NICHD Brain and Tissue Bank is to distribute tissue and therefore cannot endorse the studies performed or the interpretation of results. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = nov,
day = "18",
doi = "10.1016/j.neuron.2015.10.022",
language = "English (US)",
volume = "88",
pages = "659--666",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}