TY - JOUR
T1 - Correlation of West Nile virus incidence in donated blood with West Nile neuroinvasive disease rates, United States, 2010–2012
AU - Betsem, Edouard
AU - Kaidarova, Zhanna
AU - Stramer, Susan L.
AU - Shaz, Beth
AU - Sayers, Merlyn
AU - LeParc, German
AU - Custer, Brian
AU - Busch, Michael P.
AU - Murphy, Edward L.
N1 - Funding Information:
Financial support was provided by Blood Research Institute (training grant NHLBI K24-75036 to E.L.M.) and the government of Monaco through the Institut Pasteur (training award to E.B.).
Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - Over the past decade, West Nile virus (WNV) has spread across the United States. We aggregated blood donor data from 2010-2012 and then calculated the incidence of WNV RNA-positive donations and compared the incidence with neuroinvasive disease (NID) case data from the ArboNET surveillance system. Of 10,107,853 donations, 640 were confirmed positive. The seasonal WNV incidence rate per 100,000 persons was 33.4 (95% CI 22-45) in 2010, 25.7 (95% CI 15-34) in 2011, and 119.9 (95% CI 98-141) in 2012. NID to blood donor ratios were 1 in 164 (95% CI 152-178) in 2010, 1 in 158 (95% CI 145-174) in 2011, and 1 in 131 (95% CI 127-136) in 2012. We updated estimates of the ratio of NID to WNV infection rates, demonstrating stable disease penetrance over the study period. Blood donor WNV RNA screening is a valuable public health tool for WNV surveillance.
AB - Over the past decade, West Nile virus (WNV) has spread across the United States. We aggregated blood donor data from 2010-2012 and then calculated the incidence of WNV RNA-positive donations and compared the incidence with neuroinvasive disease (NID) case data from the ArboNET surveillance system. Of 10,107,853 donations, 640 were confirmed positive. The seasonal WNV incidence rate per 100,000 persons was 33.4 (95% CI 22-45) in 2010, 25.7 (95% CI 15-34) in 2011, and 119.9 (95% CI 98-141) in 2012. NID to blood donor ratios were 1 in 164 (95% CI 152-178) in 2010, 1 in 158 (95% CI 145-174) in 2011, and 1 in 131 (95% CI 127-136) in 2012. We updated estimates of the ratio of NID to WNV infection rates, demonstrating stable disease penetrance over the study period. Blood donor WNV RNA screening is a valuable public health tool for WNV surveillance.
UR - http://www.scopus.com/inward/record.url?scp=85009997105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009997105&partnerID=8YFLogxK
U2 - 10.3201/eid2302.161058
DO - 10.3201/eid2302.161058
M3 - Article
C2 - 27935796
AN - SCOPUS:85009997105
SN - 1080-6040
VL - 23
SP - 212
EP - 219
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 2
ER -