TY - JOUR
T1 - Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology
T2 - A retrospective analysis of 1617 cases
AU - Chen, Liqing
AU - Zhu, Kaibo
AU - Chen, Hao
AU - Liu, Qin
AU - Zhang, Xiaofei
AU - Zhou, Xin
AU - Zhang, Jun
AU - Niu, Shuang
AU - Zhou, Feng
N1 - Publisher Copyright:
© 2023 The Authors. Diagnostic Cytopathology published by Wiley Periodicals LLC.
PY - 2024/1
Y1 - 2024/1
N2 - Aims: To evaluate the immediate risk of cervical squamous cell precancers and cancers in women with low-grade squamous intraepithelial lesion (LSIL) cytology according to different high-risk human papillomavirus (hrHPV) results and age stratification. Methods: The study included 1617 women with LSIL cytology and underwent simultaneous Aptima HPV genotyping (E6/E7 mRNA test) followed by cervical biopsy. Results: Among 1317 hrHPV positive cases, other 11 types of hrHPV were the most frequent (68.8%), followed by HPV16 (11.1%), HPV18/45 (4.1%), and HPV16/HPV18/45 (0.5%). Compared to other groups, HPV18/45 positive group and other 11 types of hrHPV group showed significantly higher prevalence of intraepithelial neoplasia grade (CIN)1 (p <.0001), while HPV16 positive and HPV16/HPV18/45 dual positive groups showed significantly higher prevalence of CIN2/3 (p <.0001). In addition, hrHPV positive, 25–39 years-old age group showed a significantly higher prevalence of CIN1 (p =.032) than the other age groups. Furthermore, CIN1 prevalence was significantly higher in patients under 40 or 50 years of age than in those over 40 or 50 years of age (p =.005 and p =.011, respectively). However, there was no significant difference among the different age groups in CIN2/3 prevalence in women with LSIL cytology. Conclusion: In southern Chinese women population, LSIL cytology carries very low immediate risk of high-grade squamous intraepithelial lesions (HSIL) (CIN2/3) in general. However, HPV16 positive and HPV16/HPV18/45 dual positive indicated a higher immediate risk of high-grade squamous intraepithelial lesions (HSIL) (CIN2/3). Age is not an immediate risk factor in this patient population for high-grade squamous lesions or SCC. These results are similar to data from cytology laboratories in the United States and other international settings, therefore strongly support the usage of ASCCP guidelines in this patient population.
AB - Aims: To evaluate the immediate risk of cervical squamous cell precancers and cancers in women with low-grade squamous intraepithelial lesion (LSIL) cytology according to different high-risk human papillomavirus (hrHPV) results and age stratification. Methods: The study included 1617 women with LSIL cytology and underwent simultaneous Aptima HPV genotyping (E6/E7 mRNA test) followed by cervical biopsy. Results: Among 1317 hrHPV positive cases, other 11 types of hrHPV were the most frequent (68.8%), followed by HPV16 (11.1%), HPV18/45 (4.1%), and HPV16/HPV18/45 (0.5%). Compared to other groups, HPV18/45 positive group and other 11 types of hrHPV group showed significantly higher prevalence of intraepithelial neoplasia grade (CIN)1 (p <.0001), while HPV16 positive and HPV16/HPV18/45 dual positive groups showed significantly higher prevalence of CIN2/3 (p <.0001). In addition, hrHPV positive, 25–39 years-old age group showed a significantly higher prevalence of CIN1 (p =.032) than the other age groups. Furthermore, CIN1 prevalence was significantly higher in patients under 40 or 50 years of age than in those over 40 or 50 years of age (p =.005 and p =.011, respectively). However, there was no significant difference among the different age groups in CIN2/3 prevalence in women with LSIL cytology. Conclusion: In southern Chinese women population, LSIL cytology carries very low immediate risk of high-grade squamous intraepithelial lesions (HSIL) (CIN2/3) in general. However, HPV16 positive and HPV16/HPV18/45 dual positive indicated a higher immediate risk of high-grade squamous intraepithelial lesions (HSIL) (CIN2/3). Age is not an immediate risk factor in this patient population for high-grade squamous lesions or SCC. These results are similar to data from cytology laboratories in the United States and other international settings, therefore strongly support the usage of ASCCP guidelines in this patient population.
KW - E6/E7 mRNA genotyping
KW - LSIL
KW - hrHPV
KW - risk stratification
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U2 - 10.1002/dc.25229
DO - 10.1002/dc.25229
M3 - Article
C2 - 37740483
AN - SCOPUS:85171878219
SN - 8755-1039
VL - 52
SP - 10
EP - 15
JO - Diagnostic cytopathology
JF - Diagnostic cytopathology
IS - 1
ER -