Correlation between parameters describing tumour motion and its location in the lungs

Huanmei Wu, George Sandison, Li Zhao, Qingya Zhao, Hiroki Shirato, Steve Jiang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Characterizing respiratory-induced tumour motion is an important step in the effective image-guided radiation treatment of moving tumours, especially for tumours in the lung and lower abdomen. This study characterized tumour motion based on a piecewise linear model representing tumour motion at defined stages of the breathing cycle. Lung tumour locations were categorized based on broncho-pulmonary segments. Association rules between tumour motion characteristics and their locations in the lung were discovered and parameterized through statistical analysis. Results show there is a correlation between tumour motion characteristics and tumour location in the lungs. Generally, tumours with small motion (amplitude < 10mm) are observed most frequently in the apex region of lung or when attached to a fixed structure, such as the chest wall or aorta. Tumours with relatively large motion (amplitude > 20mm) are located close to the diaphragm or mid-level periphery of the lungs close to the chest wall.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalAustralasian Physical and Engineering Sciences in Medicine
Issue number4
StatePublished - Dec 1 2007


  • Correlations
  • Respiratory motion
  • Tumour locations

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)


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