Correlating function and imaging measures of the medial longitudinal fasciculus

Ken Sakaie, Masaya Takahashi, Gina Remington, Xiaofeng Wang, Amy Conger, Darrel Conger, Ivan Dimitrov, Stephen Jones, Ashley Frohman, Teresa Frohman, Koji Sagiyama, Osamu Togao, Robert J. Fox, Elliot Frohman

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4 Scopus citations


Objective: To test the validity of diffusion tensor imaging (DTI) measures of tissue injury by examining such measures in a white matter structure with well-defined function, the medial longitudinal fasciculus (MLF). Injury to the MLF underlies internuclear ophthalmoparesis (INO). Methods: 40 MS patients with chronic INO and 15 healthy controls were examined under an IRB-approved protocol. Tissue integrity of the MLF was characterized by DTI parameters: longitudinal diffusivity (LD), transverse diffusivity (TD), mean diffusivity (MD) and fractional anisotropy (FA). Severity of INO was quantified by infrared oculography to measure versional disconjugacy index (VDI). Results: LD was significantly lower in patients than in controls in the medulla-pons region of the MLF (p < 0.03). FA was also lower in patients in the same region (p < 0.0004). LD of the medullapons region correlated with VDI (R = -0.28, p < 0.05) as did FA in the midbrain section (R = 0.31, p < 0.02). Conclusions: This study demonstrates that DTI measures of brain tissue injury can detect injury to a functionally relevant white matter pathway, and that such measures correlate with clinically accepted evaluation indices for INO. The results validate DTI as a useful imaging measure of tissue integrity.

Original languageEnglish (US)
Article numbere0147863
JournalPloS one
Issue number1
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • General


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