Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial

Viviany R. Taqueti; Amil M. Shah; Brendan M. Everett; Aruna D. Pradhan; Gregory Piazza; Courtney Bibbo; Jon Hainer; Victoria Morgan; Ana Carolina do A. H. de Souza; Hicham Skali; Ron Blankstein; Sharmila Dorbala; Samuel Z. Goldhaber; Michel R. Le May; Benjamin J.W. Chow; Robert A. deKemp; Fadi G. Hage; Rob S. Beanlands; Peter Libby; Robert J. Glynn; Scott D. Solomon; Paul M. Ridker; Marcelo F. Di Carli

doi:10.1016/j.jacbts.2022.08.009

Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial

Viviany R. Taqueti, Amil M. Shah, Brendan M. Everett, Aruna D. Pradhan, Gregory Piazza, Courtney Bibbo, Jon Hainer, Victoria Morgan, Ana Carolina do A. H. de Souza, Hicham Skali, Ron Blankstein, Sharmila Dorbala, Samuel Z. Goldhaber, Michel R. Le May, Benjamin J.W. Chow, Robert A. deKemp, Fadi G. Hage, Rob S. Beanlands, Peter Libby, Robert J. GlynnScott D. Solomon, Paul M. Ridker, Marcelo F. Di Carli

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease.

Original language	English (US)
Pages (from-to)	141-151
Number of pages	11
Journal	JACC: Basic to Translational Science
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2022.08.009
State	Published - Feb 2023
Externally published	Yes

Keywords

cardiometabolic disease
cardiovascular trial coronary flow reserve
coronary microvascular dysfunction
heart failure
inflammation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2022.08.009

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Taqueti, V. R., Shah, A. M., Everett, B. M., Pradhan, A. D., Piazza, G., Bibbo, C., Hainer, J., Morgan, V., Carolina do A. H. de Souza, A., Skali, H., Blankstein, R., Dorbala, S., Goldhaber, S. Z., Le May, M. R., Chow, B. J. W., deKemp, R. A., Hage, F. G., Beanlands, R. S., Libby, P., ... Di Carli, M. F. (2023). Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial. JACC: Basic to Translational Science, 8(2), 141-151. https://doi.org/10.1016/j.jacbts.2022.08.009

Taqueti, VR, Shah, AM, Everett, BM, Pradhan, AD, Piazza, G, Bibbo, C, Hainer, J, Morgan, V, Carolina do A. H. de Souza, A, Skali, H, Blankstein, R, Dorbala, S, Goldhaber, SZ, Le May, MR, Chow, BJW, deKemp, RA, Hage, FG, Beanlands, RS, Libby, P, Glynn, RJ, Solomon, SD, Ridker, PM & Di Carli, MF 2023, 'Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial', JACC: Basic to Translational Science, vol. 8, no. 2, pp. 141-151. https://doi.org/10.1016/j.jacbts.2022.08.009

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abstract = "Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease.",

keywords = "cardiometabolic disease, cardiovascular trial coronary flow reserve, coronary microvascular dysfunction, heart failure, inflammation",

author = "Taqueti, {Viviany R.} and Shah, {Amil M.} and Everett, {Brendan M.} and Pradhan, {Aruna D.} and Gregory Piazza and Courtney Bibbo and Jon Hainer and Victoria Morgan and {Carolina do A. H. de Souza}, Ana and Hicham Skali and Ron Blankstein and Sharmila Dorbala and Goldhaber, {Samuel Z.} and {Le May}, {Michel R.} and Chow, {Benjamin J.W.} and deKemp, {Robert A.} and Hage, {Fadi G.} and Beanlands, {Rob S.} and Peter Libby and Glynn, {Robert J.} and Solomon, {Scott D.} and Ridker, {Paul M.} and {Di Carli}, {Marcelo F.}",

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doi = "10.1016/j.jacbts.2022.08.009",

language = "English (US)",

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AU - Taqueti, Viviany R.

AU - Shah, Amil M.

AU - Everett, Brendan M.

AU - Pradhan, Aruna D.

AU - Piazza, Gregory

AU - Bibbo, Courtney

AU - Hainer, Jon

AU - Morgan, Victoria

AU - Carolina do A. H. de Souza, Ana

AU - Skali, Hicham

AU - Blankstein, Ron

AU - Dorbala, Sharmila

AU - Goldhaber, Samuel Z.

AU - Le May, Michel R.

AU - Chow, Benjamin J.W.

AU - deKemp, Robert A.

AU - Hage, Fadi G.

AU - Beanlands, Rob S.

AU - Libby, Peter

AU - Glynn, Robert J.

AU - Solomon, Scott D.

AU - Ridker, Paul M.

AU - Di Carli, Marcelo F.

PY - 2023/2

Y1 - 2023/2

N2 - Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease.

AB - Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease.

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Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial

Abstract

Keywords

ASJC Scopus subject areas

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