TY - JOUR
T1 - Coronary atherosclerosis imaging by coronary CT angiography
T2 - Current status, correlation with intravascular interrogation and meta-analysis
AU - Voros, Szilard
AU - Rinehart, Sarah
AU - Qian, Zhen
AU - Joshi, Parag
AU - Vazquez, Gustavo
AU - Fischer, Collin
AU - Belur, Pallavi
AU - Hulten, Edward
AU - Villines, Todd C.
N1 - Funding Information:
Dr. Voros has received research grants from for Abbott Vascular , Volcano Inc. , Vital Images , Siemens Medical Solutions , and Toshiba America Medical Systems . All other authors have reported that they have no relationships to disclose.
PY - 2011/5
Y1 - 2011/5
N2 - Coronary computed tomography angiography (CTA) allows coronary artery visualization and the detection of coronary stenoses. In addition; it has been suggested as a novel, noninvasive modality for coronary atherosclerotic plaque detection, characterization, and quantification. Emerging data show that coronary CTA-based semiquantitative plaque characterization and quantification are sufficiently reproducible for clinical purposes, and fully quantitative approaches may be appropriate for use in clinical trials. Furthermore, several lines of investigation have validated plaque imaging by coronary CTA against other imaging modalities such as intravascular ultrasound/"virtual histology" and optical coherence tomography, and there are emerging data using biochemical modalities such as near-infrared spectroscopy. Finally, clinical validation in patients with acute coronary syndrome and in the outpatient setting has shown incremental value of CTA-based plaque characterization for the prediction of major cardiovascular events. With recent developments in image acquisition and reconstruction technologies, coronary CTA can be performed with relatively low radiation exposure. With further technological innovation and clinical research, coronary CTA may become an important tool in the quest to identify vulnerable plaques and the at-risk patient.
AB - Coronary computed tomography angiography (CTA) allows coronary artery visualization and the detection of coronary stenoses. In addition; it has been suggested as a novel, noninvasive modality for coronary atherosclerotic plaque detection, characterization, and quantification. Emerging data show that coronary CTA-based semiquantitative plaque characterization and quantification are sufficiently reproducible for clinical purposes, and fully quantitative approaches may be appropriate for use in clinical trials. Furthermore, several lines of investigation have validated plaque imaging by coronary CTA against other imaging modalities such as intravascular ultrasound/"virtual histology" and optical coherence tomography, and there are emerging data using biochemical modalities such as near-infrared spectroscopy. Finally, clinical validation in patients with acute coronary syndrome and in the outpatient setting has shown incremental value of CTA-based plaque characterization for the prediction of major cardiovascular events. With recent developments in image acquisition and reconstruction technologies, coronary CTA can be performed with relatively low radiation exposure. With further technological innovation and clinical research, coronary CTA may become an important tool in the quest to identify vulnerable plaques and the at-risk patient.
KW - atherosclerosis
KW - coronary computed tomography angiography
KW - intravascular ultrasound
KW - meta-analysis
KW - near-infrared spectroscopy
KW - plaque imaging
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U2 - 10.1016/j.jcmg.2011.03.006
DO - 10.1016/j.jcmg.2011.03.006
M3 - Review article
C2 - 21565743
AN - SCOPUS:79955978321
SN - 1936-878X
VL - 4
SP - 537
EP - 548
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 5
ER -