TY - JOUR
T1 - Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty
AU - Awwad, Shady T.
AU - Haddad, Walid
AU - Wang, Ming X.
AU - Parmar, Dipak
AU - Conger, Darrel
AU - Cavanagh, Harrison D
PY - 2004/7/1
Y1 - 2004/7/1
N2 - Background. An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin-polymixin B - dexamethasone ophthalmic ointment. Methods. A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed. Results. Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea. Conclusions. Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.
AB - Background. An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin-polymixin B - dexamethasone ophthalmic ointment. Methods. A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed. Results. Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea. Conclusions. Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.
KW - Confocal microscopy
KW - Cornea
KW - Crystals
KW - Gatifloxacin
KW - Penetrating keratoplasty
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U2 - 10.1097/01.ICL.0000133241.56713.2F
DO - 10.1097/01.ICL.0000133241.56713.2F
M3 - Article
C2 - 15499240
AN - SCOPUS:16544369826
SN - 1542-2321
VL - 30
SP - 169
EP - 172
JO - Eye and Contact Lens
JF - Eye and Contact Lens
IS - 3
ER -