Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty

Shady T. Awwad, Walid Haddad, Ming X. Wang, Dipak Parmar, Darrel Conger, Harrison D Cavanagh

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Background. An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin-polymixin B - dexamethasone ophthalmic ointment. Methods. A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed. Results. Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea. Conclusions. Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalEye and Contact Lens
Issue number3
StatePublished - Jul 1 2004


  • Confocal microscopy
  • Cornea
  • Crystals
  • Gatifloxacin
  • Penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology


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