@article{a43689136b1a4d15a3e6dae627096603,
title = "Coordinated transcription of key pathways in the mouse by the circadian clock",
abstract = "In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liver. Our analysis revealed ∼650 cycling transcripts and showed that the majority of these were specific to either the SCN or the liver. Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components. Major processes regulated by the SCN and liver were found to be under circadian regulation. Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology.",
author = "Satchidananda Panda and Antoch, {Marina P.} and Miller, {Brooke H.} and Su, {Andrew I.} and Schook, {Andrew B.} and Marty Straume and Schultz, {Peter G.} and Kay, {Steve A.} and Takahashi, {Joseph S.} and Hogenesch, {John B.}",
note = "Funding Information: This work is supported by the Novartis Research Foundation, the National Science Foundation (NSF) Center for Biological Timing, and the National Institute of Mental Health (NIMH #MH51573). J.S.T. is an Investigator in the Howard Hughes Medical Institute. B.H.M. is the recipient of an NSF Graduate Research Fellowship. The authors would like to thank Keith Ching for his annotation of genes represented on the arrays. The authors would like to acknowledge Drs. Martha Vitaterna and Lisa Wilsbacher for assistance with tissue collection and Jennifer Villasenor for her excellent technical assistance. The authors would like to thank Drs. Joel Kreps, Stacey Harmer, Tony Orth, Trey Sato, and Fernanda Ceriani for helpful comments on the manuscript.",
year = "2002",
month = may,
day = "3",
doi = "10.1016/S0092-8674(02)00722-5",
language = "English (US)",
volume = "109",
pages = "307--320",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",
}