TY - JOUR
T1 - Coordinate regulation of gallbladder motor function in the gut-liver axis
AU - Portincasa, Piero
AU - Di Ciaula, Agostino
AU - Wang, Helen H.
AU - Palasciano, Giuseppe
AU - Van Erpecum, Karel J.
AU - Moschetta, Antonio
AU - Wang, David Q H
PY - 2008/6
Y1 - 2008/6
N2 - Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%-15% in adults living in the western world, where cholesterol-enriched gallstones represent 75%-80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease. Indeed, a fine coordinated hepatobiliary and gastrointestinal function, including gallbladder motility in the fasting and postprandial state, is of crucial importance to prevent crystallization and precipitation of excess cholesterol in gallbladder bile. Also, gallbladder itself plays a physiopathological role in biliary lipid absorption. Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation.
AB - Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%-15% in adults living in the western world, where cholesterol-enriched gallstones represent 75%-80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease. Indeed, a fine coordinated hepatobiliary and gastrointestinal function, including gallbladder motility in the fasting and postprandial state, is of crucial importance to prevent crystallization and precipitation of excess cholesterol in gallbladder bile. Also, gallbladder itself plays a physiopathological role in biliary lipid absorption. Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation.
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U2 - 10.1002/hep.22204
DO - 10.1002/hep.22204
M3 - Review article
C2 - 18506897
AN - SCOPUS:44849102561
SN - 0270-9139
VL - 47
SP - 2112
EP - 2126
JO - Hepatology
JF - Hepatology
IS - 6
ER -