Abstract
Deuterated arachidonic acid and 20-HETE were prepared in good overall yields and high stereoselectivities. Key transformations include a trans-specific vinyl dibromide reduction and Suzuki cross-couplings to a lithium borate or a 9-BBN borane. These standards are three and two mass units higher, respectively, than their naturally occurring counterparts and are useful in mass spectrometry analysis.
Original language | English (US) |
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Pages (from-to) | 245-252 |
Number of pages | 8 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 49 |
Issue number | 3 |
DOIs | |
State | Published - Mar 15 2006 |
Keywords
- H-labeled standards
- Stereoselective
- Suzuki cross-coupling
- Z-vinyl bromide
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry