Controlling for Multiplicity, Eligibility, and Exclusions

Amber Salter; J. Philip Miller

doi:10.1007/978-3-319-52636-2_210

Controlling for Multiplicity, Eligibility, and Exclusions

Amber Salter, J. Philip Miller

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Multiple comparison procedures play an important role in controlling the accuracy of clinical trial results while trial eligibility and exclusions have the potential to introduce bias and reduce external validity. This chapter introduces the issues and sources of multiplicity and provides a description of the many different procedures that can be used to address multiplicity primarily used in the confirmatory clinical trial setting. Additionally, trial inclusion/exclusion criteria and enrichment strategies are reviewed.

Original language	English (US)
Title of host publication	Principles and Practice of Clinical Trials
Publisher	Springer International Publishing
Pages	729-737
Number of pages	9
ISBN (Electronic)	9783319526362
ISBN (Print)	9783319526355
DOIs	https://doi.org/10.1007/978-3-319-52636-2_210
State	Published - Jan 1 2022
Externally published	Yes

Keywords

Enrichment strategies
Inclusion/exclusion criteria
Multiple comparison procedures

ASJC Scopus subject areas

General Medicine
General Mathematics

Access to Document

10.1007/978-3-319-52636-2_210

Cite this

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Controlling for Multiplicity, Eligibility, and Exclusions

Abstract

Keywords

ASJC Scopus subject areas

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