TY - JOUR
T1 - Controlled drug release from hydrogel nanoparticle networks
AU - Huang, Gang
AU - Gao, Jun
AU - Hu, Zhibing
AU - St. John, John V.
AU - Ponder, Bill C.
AU - Moro, Dan
N1 - Funding Information:
Z.H. gratefully acknowledges the financial support from the US Army Research Office under Grant No. DAAD19-01-1-0596, the Texas Advanced Technology Program and Access Pharmaceuticals, Inc.
PY - 2004/2/10
Y1 - 2004/2/10
N2 - Monodisperse nanoparticles of poly-N-isopropylacrylamide-co-allylamine (PNIPAM-co-allylamine) and PNIPAM-co-acrylic acid (PNIPAM-co-AA) were synthesized. The close-packed PNIPAM-co-allylamine and PNIPAM-co-AA nanoparticles were converted to three-dimensional gel networks by covalently crosslinking neighboring particles at room temperature and neutral pH using glutaric dialdehyde and adipic acid dihydrazide, respectively. Controlled release studies were conducted using dextran markers of various molecular weights as model macromolecular drugs. Release was quantified under various physical conditions, including a range of temperatures and dextran molecular weights. Dextran, entrapped in cavities in the nanoparticle network, was released with a rate regulated by their molecular weights and cavity size. No release from a conventional bulk PNIPAM gel, with high crosslinking density, was observed. The rate of release from the PNIPAM-co-allylamine network was temperature-dependant, being much faster at room temperature than that at human body temperature. In contrast, release of low molecular weight dextrans from the PNIPAM-co-AA network showed a temperature-independent release profile. These nanoparticle networks have several advantages over conventional bulk gels for controlling the release of high molecular weight biomolecules.
AB - Monodisperse nanoparticles of poly-N-isopropylacrylamide-co-allylamine (PNIPAM-co-allylamine) and PNIPAM-co-acrylic acid (PNIPAM-co-AA) were synthesized. The close-packed PNIPAM-co-allylamine and PNIPAM-co-AA nanoparticles were converted to three-dimensional gel networks by covalently crosslinking neighboring particles at room temperature and neutral pH using glutaric dialdehyde and adipic acid dihydrazide, respectively. Controlled release studies were conducted using dextran markers of various molecular weights as model macromolecular drugs. Release was quantified under various physical conditions, including a range of temperatures and dextran molecular weights. Dextran, entrapped in cavities in the nanoparticle network, was released with a rate regulated by their molecular weights and cavity size. No release from a conventional bulk PNIPAM gel, with high crosslinking density, was observed. The rate of release from the PNIPAM-co-allylamine network was temperature-dependant, being much faster at room temperature than that at human body temperature. In contrast, release of low molecular weight dextrans from the PNIPAM-co-AA network showed a temperature-independent release profile. These nanoparticle networks have several advantages over conventional bulk gels for controlling the release of high molecular weight biomolecules.
KW - Controlled release
KW - Gel
KW - N- Isopropylacrylamide
KW - Nanoparticles
KW - Nanostructures
KW - Thermoresponsive gel
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U2 - 10.1016/j.jconrel.2003.10.007
DO - 10.1016/j.jconrel.2003.10.007
M3 - Article
C2 - 14744482
AN - SCOPUS:1642523582
SN - 0168-3659
VL - 94
SP - 303
EP - 311
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2-3
ER -