Control of muscle development by dueling HATs and HDACs

T. A. McKinsey, Li Zhang Chun Li Zhang, E. N. Olson

Research output: Contribution to journalReview articlepeer-review

356 Scopus citations


Skeletal muscle cells have provided an especially auspicious system in which to dissect the roles of chromatin structure in the control of cell growth, differentiation, and development. The MyoD and MEF2 families of transcription factors act cooperatively to regulate the expression of skeletal muscle-specific genes. Recent studies have shown that these two classes of transcription factors associate with histone acetyltransferases and histone deacetylases to control the activation and repression, respectively, of the muscle differentiation program. Signaling systems that regulate the growth and differentiation of muscle cells act, at least in part, by regulating the intracellular localization and associations of these chromatin remodeling enzymes with myogenic transcription factors. We describe the molecules and mechanisms involved in chromatin remodeling during skeletal muscle development.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 1 2001

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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