Control of EGF receptor signaling by clathrin-mediated endocytosis

Amandio V. Vieira; Christophe Lamaze; Sandra L. Schmid

doi:10.1126/science.274.5295.2086

Control of EGF receptor signaling by clathrin-mediated endocytosis

Amandio V. Vieira, Christophe Lamaze, Sandra L. Schmid

Research output: Contribution to journal › Article › peer-review

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Abstract

Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up- regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.

Original language	English (US)
Pages (from-to)	2086-2089
Number of pages	4
Journal	Science
Volume	274
Issue number	5295
DOIs	https://doi.org/10.1126/science.274.5295.2086
State	Published - Dec 20 1996

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title = "Control of EGF receptor signaling by clathrin-mediated endocytosis",

abstract = "Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up- regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.",

author = "Vieira, {Amandio V.} and Christophe Lamaze and Schmid, {Sandra L.}",

year = "1996",

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AU - Vieira, Amandio V.

AU - Lamaze, Christophe

AU - Schmid, Sandra L.

PY - 1996/12/20

Y1 - 1996/12/20

N2 - Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up- regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.

AB - Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up- regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.

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Control of EGF receptor signaling by clathrin-mediated endocytosis

Abstract

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