Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest

David R. Busch; Craig G. Rusin; Wanda Miller-Hance; Kathy Kibler; Wesley B. Baker; Jeffrey S. Heinle; Charles D. Fraser; Arjun G. Yodh; Daniel J. Licht; Kenneth M. Brady

doi:10.1364/BOE.7.003461

Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest

David R. Busch, Craig G. Rusin, Wanda Miller-Hance, Kathy Kibler, Wesley B. Baker, Jeffrey S. Heinle, Charles D. Fraser, Arjun G. Yodh, Daniel J. Licht, Kenneth M. Brady

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.

Original language	English (US)
Article number	#266921
Pages (from-to)	3461-3470
Number of pages	10
Journal	Biomedical Optics Express
Volume	7
Issue number	9
DOIs	https://doi.org/10.1364/BOE.7.003461
State	Published - Sep 1 2016
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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title = "Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest",

abstract = "While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.",

author = "Busch, {David R.} and Rusin, {Craig G.} and Wanda Miller-Hance and Kathy Kibler and Baker, {Wesley B.} and Heinle, {Jeffrey S.} and Fraser, {Charles D.} and Yodh, {Arjun G.} and Licht, {Daniel J.} and Brady, {Kenneth M.}",

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AU - Busch, David R.

AU - Rusin, Craig G.

AU - Miller-Hance, Wanda

AU - Kibler, Kathy

AU - Baker, Wesley B.

AU - Heinle, Jeffrey S.

AU - Fraser, Charles D.

AU - Yodh, Arjun G.

AU - Licht, Daniel J.

AU - Brady, Kenneth M.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.

AB - While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.

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Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest

Abstract

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