Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest

David R. Busch, Craig G. Rusin, Wanda Miller-Hance, Kathy Kibler, Wesley B. Baker, Jeffrey S. Heinle, Charles D. Fraser, Arjun G. Yodh, Daniel J. Licht, Kenneth M. Brady

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.

Original languageEnglish (US)
Article number#266921
Pages (from-to)3461-3470
Number of pages10
JournalBiomedical Optics Express
Issue number9
StatePublished - Sep 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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