Consuming fructose-sweetened beverages increases body adiposity in mice

Hella Jürgens, Wiltrud Haass, Tamara R. Castañeda, Annette Schürmann, Corinna Koebnick, Frank Dombrowski, Bärbel Otto, Andrea R. Nawrocki, Philipp E. Scherer, Jochen Spranger, Michael Ristow, Hans Georg Joost, Peter J. Havel, Matthias H. Tschöp

Research output: Contribution to journalArticlepeer-review

251 Scopus citations


Objective: The marked increase in the prevalence of obesity in the United States has recently been attributed to the increased fructose consumption. To determine if and how fructose might promote obesity in an animal model, we measured body composition, energy intake, energy expenditure, substrate oxidation, and several endocrine parameters related to energy homeostasis in mice consuming fructose. Research Methods and Procedures: We compared the effects of ad libitum access to fructose (15% solution in water), sucrose (10%, popular soft drink), and artificial sweetener (0% calories, popular diet soft drink) on adipogenesis and energy metabolism in mice. Results: Exposure to fructose water increased adiposity, whereas increased fat mass after consumption of soft drinks or diet soft drinks did not reach statistical significance (n = 9 each group). Total intake of energy was unaltered, because mice proportionally reduced their caloric intake from chow. There was a trend toward reduced energy expenditure and increased respiratory quotient, albeit not significant, in the fructose group. Furthermore, fructose produced a hepatic lipid accumulation with a characteristic pericentral pattern. Discussion: These data are compatible with the conclusion that a high intake of fructose selectively enhances adipogenesis, possibly through a shift of substrate use to lipogenesis.

Original languageEnglish (US)
Pages (from-to)1145-1156
Number of pages12
JournalObesity research
Issue number7
StatePublished - 2005


  • Energy balance
  • Energy expenditure
  • Fructose
  • Rodent
  • Soft drink

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Public Health, Environmental and Occupational Health


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