Abstract
Mucocutaneous bleeding symptoms and/or persistent thrombocytopenia occur in individuals with congenital disorders of platelet function and number. Apart from bleeding, these disorders are often associated with additional hematologic and clinical manifestations, including auditory, immunologic, and oncologic disease. Autosomal recessive, dominant, and X-linked inheritance patterns have been demonstrated. Precise delineation of the molecular cause of the platelet disorder can aid the pediatrician in the detection and prevention of specific disorder-associated manifestations and guide appropriate treatment and anticipatory care for the patient and family.
Original language | English (US) |
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Pages (from-to) | 561-578 |
Number of pages | 18 |
Journal | Pediatric clinics of North America |
Volume | 65 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2018 |
Externally published | Yes |
Keywords
- Congenital platelet disorder
- Platelet function
- Thrombasthenia
- Thrombocytopenia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health