TY - JOUR
T1 - Concentrations of antimicrobial agents in middle ear fluid, saliva and tears
AU - Nelson, John D.
AU - Ginsburg, Charles M.
AU - McLeland, Ora
AU - Clahsen, Joan
AU - Culbertson, M. C.
AU - Carder, Henry
N1 - Funding Information:
Antibiotic assays and cultures were performed by Sharon Shelton, B.A. and Teresa Zweighaft, B.A. The studies were supported by grants from Beecham Research Laboratories and Eli Lilly Laboratories. Drugs were supplied by Beecham Laboratories (amoxicillin), Eli Lilly Laboratories (erythromycin estolate), Hoffmann-La Roche Inc. (trimethoprim-sulfamethoxazole), Bristol Laboratories (penicillin V and ampicillin), and Ross Laboratories (erythromycin ethylsuccinate).
PY - 1981/12
Y1 - 1981/12
N2 - Antibiotic concentrations in middle ear fluid (MEF), saliva and tears were measured in children with persistent middle ear effusions undergoing tympanostomy tube placement. In 31 children given cefaclor, specimens of serum, saliva and MEF were collected at 0.5, 1, 2, 3 or 5 h after a dose. Another group of 37 children were randomized to receive a single dose of penicillin V, amoxicillin, ampicillin, erythromycin estolate, erythromycin ethyl-succinate, trimethoprim-sulfamethoxazole or cefaclor. Concentrations of antibiotics in saliva and tears bore no consistent relationship to those in MEF. Mean concentrations of all drugs in MEF were several-fold greater than the usual minimal inhibitory concentrations (MIC) of pneumococci, but only with trimethoprim and cefaclor were they greater than the usual MIC's for Haemophilus influenzae. Concentrations of antibiotics in MEF in persistent effusions were comparable to those previously reported in acute purulent effusions.
AB - Antibiotic concentrations in middle ear fluid (MEF), saliva and tears were measured in children with persistent middle ear effusions undergoing tympanostomy tube placement. In 31 children given cefaclor, specimens of serum, saliva and MEF were collected at 0.5, 1, 2, 3 or 5 h after a dose. Another group of 37 children were randomized to receive a single dose of penicillin V, amoxicillin, ampicillin, erythromycin estolate, erythromycin ethyl-succinate, trimethoprim-sulfamethoxazole or cefaclor. Concentrations of antibiotics in saliva and tears bore no consistent relationship to those in MEF. Mean concentrations of all drugs in MEF were several-fold greater than the usual minimal inhibitory concentrations (MIC) of pneumococci, but only with trimethoprim and cefaclor were they greater than the usual MIC's for Haemophilus influenzae. Concentrations of antibiotics in MEF in persistent effusions were comparable to those previously reported in acute purulent effusions.
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U2 - 10.1016/0165-5876(81)90057-4
DO - 10.1016/0165-5876(81)90057-4
M3 - Article
C2 - 6799415
AN - SCOPUS:0019845570
SN - 0165-5876
VL - 3
SP - 327
EP - 334
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
IS - 4
ER -