Abstract
A complex translocation has interrupted the third exon of the c-myc gene in human plasma cell myeloma tumor cells and a derivative cell line (NCI-H929). As a result of this rearrangement, a chimeric mRNA is expressed which commences 5' of the c-myc coding region and includes sequences introduced by the translocation event. All of the detectable c-myc-containing mRNA in the tumor and cell line was derived from this rearranged c-myc allele. This chimeric c-myc mRNA, in which most of the germ cell c-myc 3' untranslated region has been replaced, was greater than sevenfold more stable than c-myc transcripts with intact 3' ends. This suggests that the 3' untranslated region may play an important role in c-myc mRNA stability.
Original language | English (US) |
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Pages (from-to) | 124-129 |
Number of pages | 6 |
Journal | Molecular and cellular biology |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 1988 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology