Complex translocation disrupts c-myc regulation in a human plasma cell myeloma

G. F. Hollis, A. F. Gazdar, V. Bertness, I. R. Kirsch

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


A complex translocation has interrupted the third exon of the c-myc gene in human plasma cell myeloma tumor cells and a derivative cell line (NCI-H929). As a result of this rearrangement, a chimeric mRNA is expressed which commences 5' of the c-myc coding region and includes sequences introduced by the translocation event. All of the detectable c-myc-containing mRNA in the tumor and cell line was derived from this rearranged c-myc allele. This chimeric c-myc mRNA, in which most of the germ cell c-myc 3' untranslated region has been replaced, was greater than sevenfold more stable than c-myc transcripts with intact 3' ends. This suggests that the 3' untranslated region may play an important role in c-myc mRNA stability.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalMolecular and cellular biology
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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