TY - JOUR
T1 - Comparison of trimethoprim-sulfamethoxazole and ampicillin therapy for shigellosis in ambulatory patients
AU - Nelson, John D.
AU - Kusmiesz, Helen
AU - Jackson, Lula Hinton
N1 - Funding Information:
Susceptibility testing was performed by Edythe Woodman. The authors are gratefnl to the pediatric residents for their cooperation. The study was supported by a grant from Hoffmann-LaRoche, lnc.
PY - 1976/9
Y1 - 1976/9
N2 - One hundred seventy-four infants and children with acute diarrhea were treated as ambulatory patients with either ampicillin (100 mg/kg/day orally in four divided doses) or trimethoprim sulfamethoxazole (10 mg TMP and 50 mg SMX/kg/day orally in two divided doses). There were 65 patients with shigellosis. Responses of those treated with TMP/SMX and of those with susceptible Shigella treated with ampicillin were comparable. Patients with resistant organisms failed to respond to ampicillin. All Shigella, including ampicillin-resistant strains, were susceptible in vitro to TMP/SMX, and patients with ampicillin-resistant strains responded favorably to treatment with TMP/SMX. TMP/SMX appears to be the best, currently available drug for the treatment of shigellosis.
AB - One hundred seventy-four infants and children with acute diarrhea were treated as ambulatory patients with either ampicillin (100 mg/kg/day orally in four divided doses) or trimethoprim sulfamethoxazole (10 mg TMP and 50 mg SMX/kg/day orally in two divided doses). There were 65 patients with shigellosis. Responses of those treated with TMP/SMX and of those with susceptible Shigella treated with ampicillin were comparable. Patients with resistant organisms failed to respond to ampicillin. All Shigella, including ampicillin-resistant strains, were susceptible in vitro to TMP/SMX, and patients with ampicillin-resistant strains responded favorably to treatment with TMP/SMX. TMP/SMX appears to be the best, currently available drug for the treatment of shigellosis.
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U2 - 10.1016/S0022-3476(76)80561-6
DO - 10.1016/S0022-3476(76)80561-6
M3 - Article
C2 - 1048183
AN - SCOPUS:0017190298
SN - 0022-3476
VL - 89
SP - 491
EP - 493
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -