Twenty-four patients with severe shigellosis were treated with intramuscular ampicillin, 100 mg. per kilogram per day in 4 divided doses for 5 days. They were compared with patients previously treated orally with the same dosage of ampicillin. Clearing of Shigellae from the stools was significantly more rapid with the intramuscular route of administration. Alterations in enteric flora were different in the 2 groups. Patients treated orally were more likely to have the intestinal flora replaced with Candida species in contrast with those treated parenterally who were more apt to have overgrowth with species of Klebsiella-Aerobacter. Though each mode of ampicillin administration is effective in the treatment of shigellosis, the intramuscular route results in a more prompt eradication of Shigellae and is useful in the treatment of patients who are not able to take medication orally.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health