Comparison of calcium phosphate preparations for onlay cranial augmentation in a murine model

Alexis D. Furze, Michael R. Lee, Karen Pawlowski, Chrisovalantis Lakhiani, Joseph L. Leach

Research output: Contribution to journalArticlepeer-review


Calcium phosphate preparations are often employed for a variety of reconstructive tasks. The majority of existing data regarding these preparations relates to their use as an inlay implant. The present study aims to evaluate calcium phosphate preparations and their tissue characteristics related to onlay augmentation. Thirty-six research mice were divided into three groups of 12. Each animal underwent onlay augmentation with a calcium phosphate preparation. Group 1 members were subjected to hydroxyapatite (HA) paste while group 2 was treated with beta-tricalcium phosphate granules alone (TCP). Finally, group 3 was treated with a combined mixture of both substances (HA-TCP). The animals were harvested for histological analysis and data collection. Groups 2 (TCP) and 3 (HA-TCP) developed greater osteoneogenesis and tissue integration compared to Group 1 (HA). The results were found to be statistically significant (p<0.01). Calcium phosphate preparations including TCP alone or in combination with HA undergo greater osteoneogenesis and soft tissue integration compared with hydroxapatite alone when used as an onlay implant in the animal model. Therapeutic study - Level II.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalEuropean Journal of Plastic Surgery
Issue number7
StatePublished - Jul 1 2012


  • Augmentation
  • Biomaterials
  • Bone substitutes
  • Bony reconstruction
  • Calciumphosphate
  • Hydroxyapatite
  • Implant
  • Onlay implantation
  • Tricalcium phosphate

ASJC Scopus subject areas

  • Surgery


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