TY - JOUR
T1 - Comparative Toxicities of Methicillin and Nafcillin
AU - Kitzing, W.
AU - Nelson, J. D.
AU - Mohs, E.
PY - 1981/1
Y1 - 1981/1
N2 - In a prospective, randomized study, 75 infants and children were treated with methicillin sodium and 74 were treated with nafcillin sodium. The two groups were comparable with regard to age, sex, duration of therapy, types of illnesses, etiologic bacteria, and bacteremia. Clinical responses were also comparable. The frequencies of fever, rash, eosinophilia, neutropenia, anemia, and abnormal hepatic enzymes were the same in the two groups. Two patients in each group had transient hematuria early in their course that resolved despite continued antibiotic therapy. Definite urologic toxic effect did not occur in patients who received nafcillin, while four (5.3%) of the methicillin-treated patients were judged to have this complication. In addition, six patients (8%) who received methicillin had questionable evidence of urologic toxic effect. It is concluded that methicillin and nafcillin have comparable clinical efficacy and adverse effects, with the exception that definite urologic toxic effect has been observed with nafcillin therapy.
AB - In a prospective, randomized study, 75 infants and children were treated with methicillin sodium and 74 were treated with nafcillin sodium. The two groups were comparable with regard to age, sex, duration of therapy, types of illnesses, etiologic bacteria, and bacteremia. Clinical responses were also comparable. The frequencies of fever, rash, eosinophilia, neutropenia, anemia, and abnormal hepatic enzymes were the same in the two groups. Two patients in each group had transient hematuria early in their course that resolved despite continued antibiotic therapy. Definite urologic toxic effect did not occur in patients who received nafcillin, while four (5.3%) of the methicillin-treated patients were judged to have this complication. In addition, six patients (8%) who received methicillin had questionable evidence of urologic toxic effect. It is concluded that methicillin and nafcillin have comparable clinical efficacy and adverse effects, with the exception that definite urologic toxic effect has been observed with nafcillin therapy.
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U2 - 10.1001/archpedi.1981.02130250040013
DO - 10.1001/archpedi.1981.02130250040013
M3 - Article
C2 - 7006381
AN - SCOPUS:0019449083
SN - 0002-922X
VL - 135
SP - 52
EP - 55
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 1
ER -