TY - JOUR
T1 - Comparative outcomes after percutaneous coronary intervention among black and white patients treated at US Veterans Affairs hospitals
AU - Kobayashi, Taisei
AU - Glorioso, Thomas J.
AU - Armstrong, Ehrin J.
AU - Maddox, Thomas M.
AU - Plomondon, Mary E.
AU - Grunwald, Gary K.
AU - Bradley, Steven M.
AU - Tsai, Thomas T.
AU - Waldo, Stephen W.
AU - Rao, Sunil V.
AU - Banerjee, Subhash
AU - Nallamothu, Brahmajee K.
AU - Bhatt, Deepak L.
AU - Rene, A. Garvey
AU - Wilensky, Robert L.
AU - Groeneveld, Peter W.
AU - Giri, Jay
N1 - Funding Information:
completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Waldo reported receiving unrelated investigator-initiated research support from Abiomed, Cardiovascular Systems Incorporated, and Merck Pharmaceuticals. Dr Bhatt reported the following relationships: advisory boards (Cardax, Elsevier Practice Update Cardiology, Medscape Cardiology, and Regado Biosciences), boards of directors (Boston Veterans Affairs Research Institute and Society of Cardiovascular Patient Care), chair (American Heart Association Quality Oversight Committee), data monitoring committees (Duke Clinical Research Institute, Harvard Clinical Research Institute, Mayo Clinic, and Population Health Research Institute), honoraria (American College of Cardiology [senior associate editor, Clinical Trials and News and ACC.org], Belvoir Publications [editor in chief, Harvard Heart Letter], Duke Clinical Research Institute [clinical trial steering committees], Harvard Clinical Research Institute [clinical trial steering committee], HMP Communications [editor in chief, The Journal of Invasive Cardiology], Journal of the American College of Cardiology [guest editor and associate editor], Population Health Research Institute [clinical trial steering committee], Slack Publications [chief medical editor, Cardiology Today’s Intervention], Society of Cardiovascular Patient Care [secretary/treasurer], and WebMD [continuing medical education steering committees]), other (Clinical Cardiology [deputy editor], National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry (NCDR-ACTION) Registry Steering Committee [chair], and Veterans Affairs Clinical Assessment, Reporting, and Tracking System (CART) Research and Publications Committee [chair]), research funding (Amarin, Amgen, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Forest Laboratories, Ischemix, Medtronic, Pfizer, Roche, Sanofi, and The Medicines Company), royalties (Elsevier [editor, Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease]), site coinvestigator (Biotronik, Boston Scientific, and St Jude Medical), trustee (American College of Cardiology), and unfunded research (FlowCo, PLx Pharma, and Takeda). No other disclosures were reported.
Publisher Copyright:
© 2017 American Medical Association. All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - IMPORTANCE: Current comparative outcomes among black and white patients treated with percutaneous coronary intervention (PCI) in the Veterans Affairs (VA) health system are not known. OBJECTIVE: To compare outcomes between black and white patients undergoing PCI in the VA health system. DESIGN, SETTING, AND PARTICIPANTS: This study compared black and white patients who underwent PCI between October 1, 2007, and September 30, 2013, at 63 VA hospitals using data recorded in the VA Clinical Assessment, Reporting, and Tracking System for Cardiac Catheterization Laboratories (CART-CL) program. A generalized linear mixed model with a random intercept for site assessed the relative difference in odds of outcomes between black and white patients. The setting was integrated institutionalized hospital care. Excluded were all patients of other races or those with multiple listed races and those with missing data regarding race or the diagnostic cardiac catheterization. The dates of analysis were January 7, 2016, to April 17, 2017. EXPOSURE: Percutaneous coronary intervention at a VA hospital. MAIN OUTCOMES AND MEASURES: The primary outcome was 1-year mortality. Secondary outcomes were 30-day all-cause readmission rates, 30-day acute kidney injury, 30-day blood transfusion, and 1-year readmission rates for myocardial infarction. In addition, variations in procedural and postprocedural care were examined, including the use of intravascular ultrasound, optical coherence tomography, fractional flow reserve measurements, bare-metal stents, postprocedural medications, and radial access. RESULTS: A total of 42 391 patients (13.3% black and 98.4% male; mean [SD] age, 65.2 [9.1] years) satisfied the inclusion and exclusion criteria. In unadjusted analyses, black patients had higher rates of 1-year mortality (7.1% vs 5.9%, P < .001) as well as secondary outcomes of 30-day acute kidney injury (20.8% vs 13.8%, P < .001), 30-day blood transfusion (3.4% vs 2.7%, P < .01), and 1-year readmission rates for myocardial infarction (3.3% vs 2.7%, P = .01) compared with white patients. After adjustment for demographics, comorbidities, and procedural characteristics, odds for 1-year mortality (odds ratio, 1.04; 95% CI, 0.90-1.19) were not different between black and white patients. There were also no differences in secondary outcomes with the exception of a higher rate of adjusted 30-day acute kidney injury (odds ratio, 1.22; 95% CI, 1.10-1.36). CONCLUSIONS AND RELEVANCE: While black patients had a higher rate of mortality than white patients in unadjusted analyses, race was not independently associated with 1-year mortality among patients undergoing PCI in VA hospitals.
AB - IMPORTANCE: Current comparative outcomes among black and white patients treated with percutaneous coronary intervention (PCI) in the Veterans Affairs (VA) health system are not known. OBJECTIVE: To compare outcomes between black and white patients undergoing PCI in the VA health system. DESIGN, SETTING, AND PARTICIPANTS: This study compared black and white patients who underwent PCI between October 1, 2007, and September 30, 2013, at 63 VA hospitals using data recorded in the VA Clinical Assessment, Reporting, and Tracking System for Cardiac Catheterization Laboratories (CART-CL) program. A generalized linear mixed model with a random intercept for site assessed the relative difference in odds of outcomes between black and white patients. The setting was integrated institutionalized hospital care. Excluded were all patients of other races or those with multiple listed races and those with missing data regarding race or the diagnostic cardiac catheterization. The dates of analysis were January 7, 2016, to April 17, 2017. EXPOSURE: Percutaneous coronary intervention at a VA hospital. MAIN OUTCOMES AND MEASURES: The primary outcome was 1-year mortality. Secondary outcomes were 30-day all-cause readmission rates, 30-day acute kidney injury, 30-day blood transfusion, and 1-year readmission rates for myocardial infarction. In addition, variations in procedural and postprocedural care were examined, including the use of intravascular ultrasound, optical coherence tomography, fractional flow reserve measurements, bare-metal stents, postprocedural medications, and radial access. RESULTS: A total of 42 391 patients (13.3% black and 98.4% male; mean [SD] age, 65.2 [9.1] years) satisfied the inclusion and exclusion criteria. In unadjusted analyses, black patients had higher rates of 1-year mortality (7.1% vs 5.9%, P < .001) as well as secondary outcomes of 30-day acute kidney injury (20.8% vs 13.8%, P < .001), 30-day blood transfusion (3.4% vs 2.7%, P < .01), and 1-year readmission rates for myocardial infarction (3.3% vs 2.7%, P = .01) compared with white patients. After adjustment for demographics, comorbidities, and procedural characteristics, odds for 1-year mortality (odds ratio, 1.04; 95% CI, 0.90-1.19) were not different between black and white patients. There were also no differences in secondary outcomes with the exception of a higher rate of adjusted 30-day acute kidney injury (odds ratio, 1.22; 95% CI, 1.10-1.36). CONCLUSIONS AND RELEVANCE: While black patients had a higher rate of mortality than white patients in unadjusted analyses, race was not independently associated with 1-year mortality among patients undergoing PCI in VA hospitals.
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U2 - 10.1001/jamacardio.2017.2180
DO - 10.1001/jamacardio.2017.2180
M3 - Article
C2 - 28724126
AN - SCOPUS:85032641375
SN - 2380-6583
VL - 2
SP - 967
EP - 975
JO - JAMA Cardiology
JF - JAMA Cardiology
IS - 9
ER -