Abstract
The effects of endothelin (ET-1) on smooth muscle contractile activity were investigated and compared in human saphenous vein and gastroepiploic artery, vessels frequently used in revascularization procedures. ET-1 contracted saphenous vein and gastroepiploic artery in a concentration-dependent manner. The peptide produced a greater maximal effect in the vein than in the artery and, in both preparations, ET-1 was less efficacious than U46619, an agent which mimics the actions of thromboxane A2 at the thromboxane A2/prostaglandin HZ receptor. The contractile response to ET-1 declined spontaneously at a more rapid rate in the artery than in the vein. The present data indicate that ET-1 has significant contractile activity in both vessels which are used for coronary arterial bypass surgery and suggest that although, a weaker vasoconstrictor than U46619, the peptide could induce vasospasm in both graft vessels.
Original language | English (US) |
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Pages (from-to) | 81-85 |
Number of pages | 5 |
Journal | Molecular and Cellular Biochemistry |
Volume | 117 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1992 |
Externally published | Yes |
Keywords
- endothelin
- gastroepiploic artery
- saphenous vein
- thromboxane analog
ASJC Scopus subject areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology