Comparative effect of fluorometholone acetate and flouormetholone alcohol on IOP

S. L. Hargrave, James P McCulley

Research output: Contribution to journalReview articlepeer-review


Purpose. Elevation of IOP is seen in many post-operative patients treated with topical corticosteroids. We compared the pressure raising effects of fluorometholone alcohol and fluorometholone acetate in post-operative steroid responsive patients. Methods. We prospectively evaluated 24 consecutive post-operative steroid responders (14 pk, 4 cataract, 6 other) who were treated with fluorometholone acetate and had an IOP rise. These patients were then switched to fluorometholone alcohol at the same frequency without any other medication changes. Results. 21 of 24 steroid responsive eyes that showed an increase in IOP to fluorometholone acetate had a significant decrease in IOP when switched to fluorometholone alcohol. The mean IOP with fluorometholone acetate was 28.38 mmHg ± 4.62 mmHg compared with 22.63 mmHg ± 6.72 mmHg on fluorometholone alcohol (p=0.0006). Conclusions. These results suggest that fluorometholone acetate induces a greater IOP increase in steroid responsive patients than fluorometholone alcohol.

Original languageEnglish (US)
Pages (from-to)S814
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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