Combined thrombolytic therapy for prosthetic mitral valve thrombosis

Charles M T Jost; Clyde W. Yancy; W. Steves Ring

doi:10.1016/0003-4975(93)90497-6

Combined thrombolytic therapy for prosthetic mitral valve thrombosis

Charles M T Jost, Clyde W. Yancy, W. Steves Ring

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.

Original language	English (US)
Pages (from-to)	159-161
Number of pages	3
Journal	The Annals of Thoracic Surgery
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/0003-4975(93)90497-6
State	Published - Jan 1993

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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title = "Combined thrombolytic therapy for prosthetic mitral valve thrombosis",

abstract = "Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.",

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AB - Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.

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Combined thrombolytic therapy for prosthetic mitral valve thrombosis

Abstract

ASJC Scopus subject areas

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