Abstract
The use of a combination of oral hypoglycemic drugs and insulin to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) that is refractory to treatment with oral hypoglycemic drugs alone has long been of great interest to practitioners. I cannot remember when I last gave a lecture on diabetes without being asked my opinion of the merits of combination therapy. Combination therapy makes good pathophysiologic sense. NIDDM has two main pathophysiologic features: relative insulin deficiency1 and decreased peripheral and hepatic sensitivity to insulin.2 The combination of a sulfonylurea drug that increases insulin sensitivity3 and exogenous insulin should theoretically correct both defects…
Original language | English (US) |
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Pages (from-to) | 1453-1454 |
Number of pages | 2 |
Journal | New England Journal of Medicine |
Volume | 327 |
Issue number | 20 |
DOIs | |
State | Published - Nov 12 1992 |
ASJC Scopus subject areas
- General Medicine