Combination Therapy in NIDDM

Research output: Contribution to journalEditorialpeer-review

7 Scopus citations


The use of a combination of oral hypoglycemic drugs and insulin to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) that is refractory to treatment with oral hypoglycemic drugs alone has long been of great interest to practitioners. I cannot remember when I last gave a lecture on diabetes without being asked my opinion of the merits of combination therapy. Combination therapy makes good pathophysiologic sense. NIDDM has two main pathophysiologic features: relative insulin deficiency1 and decreased peripheral and hepatic sensitivity to insulin.2 The combination of a sulfonylurea drug that increases insulin sensitivity3 and exogenous insulin should theoretically correct both defects…

Original languageEnglish (US)
Pages (from-to)1453-1454
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - Nov 12 1992

ASJC Scopus subject areas

  • Medicine(all)


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