Comb-type copolymers for controlled DNA delivery

A. Maruyama, A. Ferdous, T. Ishihara, S. Asayama, J. U. Park, M. Nogawa, H. Watanabe, Y. Takei, T. Akaike

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Various comb-type copolymer containing a polycation as a main chain was design to construct delivery systems of DNAs. The comb-type copolymers having cell-specific polysaccharides were proved to be useful to deliver DNA to the target cells in vivo. Of interest, the copolymers with abundant side chains of hydrophilic polymers are capable of stabilizing DNA triplex. Further, injectable nanoparticles for controlled releases of DNAs were fabricated from the copolymer and a biodegradable polymer.

Original languageEnglish (US)
Pages (from-to)1681-1682
Number of pages2
JournalNucleosides and Nucleotides
Issue number6-7
StatePublished - 1999

ASJC Scopus subject areas

  • Biochemistry
  • Genetics


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