Collagenolytic Activity in Experimental Herpes Simplex Keratitis

J. P. McCulley, H. H. Slansky, D. Pavan-Langston, C. H. Dohlman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Collagenolytic activity was demonstrated in the epithelium of rabbit corneas experimentally infected with herpes simplex virus in 19 of 20 trephined explants. Control epithelial explants demonstrated minimal to no collagenase activity. This finding may offer one explanation for the stromal ulcerations which can occur in herpetic keratitis. Possible mechanisms of this increased enzyme activity are discussed.

Original languageEnglish (US)
Pages (from-to)516-519
Number of pages4
JournalArchives of Ophthalmology
Issue number4
StatePublished - Oct 1970

ASJC Scopus subject areas

  • Ophthalmology


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