Collagenase Activity of Intact Corneal Epithelium in Peripheral Alkali Burns

R. R. Pfister, James P McCulley, J. Friend, C. H. Dohlman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Collagenase was produced from intact epithelium of nonulcerated rabbit corneas beginning 9 to 15 hours after an alkali burn of the perilimbal sclera. At the same time, glycogen loss from these cells generally paralleled the degree of aqueous glucose depression. Aqueous humor from alkali burned eyes failed to have either facilitative or inhibitory effects on collagenase production in vitro. Persistently low aqueous pH starting 20 minutes after peripheral alkali burning is attributed to increased aqueous lactate.

Original languageEnglish (US)
Pages (from-to)308-313
Number of pages6
JournalArchives of Ophthalmology
Issue number3
StatePublished - Sep 1971

ASJC Scopus subject areas

  • Ophthalmology


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