Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1

Jonathan M. Payne; Kristina M. Haebich; Rachel MacKenzie; Karin S. Walsh; Stephen J.C. Hearps; David Coghill; Belinda Barton; Natalie A. Pride; Nicole J. Ullrich; James H. Tonsgard; David Viskochil; Elizabeth K. Schorry; Laura Klesse; Michael J. Fisher; David H. Gutmann; Tena Rosser; Roger J. Packer; Bruce Korf; Maria T. Acosta; Mark A. Bellgrove; Kathryn N. North

doi:10.1177/1087054719894384

Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1

Jonathan M. Payne, Kristina M. Haebich, Rachel MacKenzie, Karin S. Walsh, Stephen J.C. Hearps, David Coghill, Belinda Barton, Natalie A. Pride, Nicole J. Ullrich, James H. Tonsgard, David Viskochil, Elizabeth K. Schorry, Laura Klesse, Michael J. Fisher, David H. Gutmann, Tena Rosser, Roger J. Packer, Bruce Korf, Maria T. Acosta, Mark A. BellgroveKathryn N. North

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.

Original language	English (US)
Pages (from-to)	1177-1186
Number of pages	10
Journal	Journal of Attention Disorders
Volume	25
Issue number	8
DOIs	https://doi.org/10.1177/1087054719894384
State	Published - Jun 2021

Keywords

ADHD
cognition
executive function
functional impairment
neurofibromatosis type 1

ASJC Scopus subject areas

Developmental and Educational Psychology
Clinical Psychology

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10.1177/1087054719894384

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Payne, J. M., Haebich, K. M., MacKenzie, R., Walsh, K. S., Hearps, S. J. C., Coghill, D., Barton, B., Pride, N. A., Ullrich, N. J., Tonsgard, J. H., Viskochil, D., Schorry, E. K., Klesse, L., Fisher, M. J., Gutmann, D. H., Rosser, T., Packer, R. J., Korf, B., Acosta, M. T., ... North, K. N. (2021). Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1. Journal of Attention Disorders, 25(8), 1177-1186. https://doi.org/10.1177/1087054719894384

Payne, JM, Haebich, KM, MacKenzie, R, Walsh, KS, Hearps, SJC, Coghill, D, Barton, B, Pride, NA, Ullrich, NJ, Tonsgard, JH, Viskochil, D, Schorry, EK, Klesse, L, Fisher, MJ, Gutmann, DH, Rosser, T, Packer, RJ, Korf, B, Acosta, MT, Bellgrove, MA & North, KN 2021, 'Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1', Journal of Attention Disorders, vol. 25, no. 8, pp. 1177-1186. https://doi.org/10.1177/1087054719894384

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title = "Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1",

abstract = "Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.",

keywords = "ADHD, cognition, executive function, functional impairment, neurofibromatosis type 1",

author = "Payne, {Jonathan M.} and Haebich, {Kristina M.} and Rachel MacKenzie and Walsh, {Karin S.} and Hearps, {Stephen J.C.} and David Coghill and Belinda Barton and Pride, {Natalie A.} and Ullrich, {Nicole J.} and Tonsgard, {James H.} and David Viskochil and Schorry, {Elizabeth K.} and Laura Klesse and Fisher, {Michael J.} and Gutmann, {David H.} and Tena Rosser and Packer, {Roger J.} and Bruce Korf and Acosta, {Maria T.} and Bellgrove, {Mark A.} and North, {Kathryn N.}",

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year = "2021",

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doi = "10.1177/1087054719894384",

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AU - MacKenzie, Rachel

AU - Walsh, Karin S.

AU - Hearps, Stephen J.C.

AU - Coghill, David

AU - Barton, Belinda

AU - Pride, Natalie A.

AU - Ullrich, Nicole J.

AU - Tonsgard, James H.

AU - Viskochil, David

AU - Schorry, Elizabeth K.

AU - Klesse, Laura

AU - Fisher, Michael J.

AU - Gutmann, David H.

AU - Rosser, Tena

AU - Packer, Roger J.

AU - Korf, Bruce

AU - Acosta, Maria T.

AU - Bellgrove, Mark A.

AU - North, Kathryn N.

PY - 2021/6

Y1 - 2021/6

N2 - Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.

AB - Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.

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Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1

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