@article{c25cb5c1ada9476ea2f9f69bc5bfe098,
title = "CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10",
abstract = "A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.",
keywords = "Brain metastasis, T cells, bone marrow-derived myeloid cells, brain immunity, cancer immunology, immune suppression, immune therapy, metastatic niche, microglia, tumor microenvironment",
author = "Guldner, {Ian H.} and Qingfei Wang and Lin Yang and Golomb, {Samantha M.} and Zhuo Zhao and Lopez, {Jacqueline A.} and Abigail Brunory and Howe, {Erin N.} and Yizhe Zhang and Bhavana Palakurthi and Martin Barron and Hongyu Gao and Xiaoling Xuei and Yunlong Liu and Jun Li and Chen, {Danny Z.} and Landreth, {Gary E.} and Siyuan Zhang",
note = "Funding Information: This work was funded by NIH R01 CA194697-01 and R01 CA222405-01A1 (S.Z.), Notre Dame CRND Catalyst Award (S.Z. and I.H.G.), NIH CTSI core facility pilot grants (S.Z.), and NSF CCF-1617735 (D.Z.C.). We would like to acknowledge and thank the Dee Family endowment (S.Z.). For insightful discussion and technical assistance, we thank Zhang Lab members, Vytas Bindokas, PhD, Samuel W. Brady, PhD, Kevin Brown, PhD, Andrea Gunawan, MS, Harikrishna Nakshatri, PhD, and Charles R. Tessier, PhD. We are grateful for the use of the following core facilities: Notre Dame Genomics and Bioinformatics Core Facility, Notre Dame Freimann Life Sciences Center, Harper Cancer Research Institute Biorepository, Indiana University School of Medicine South Bend Imaging and Flow Cytometry Core, University of Chicago Integrated Light Microscopy Facility, Indiana University Simon Cancer Center Core Facility, and Michigan State University Genomics Core. I.H.G. and S.Z. conceived original hypothesis and designed experiments. I.H.G. Q.W. S.M.G. J.A.L. A.B. E.N.H. B.P. H.G. X.X. and S.Z. performed experiments. I.H.G. L.Y. S.M.G. Z.Z. A.B. Y.Z. M.B. J.L. and S.Z. analyzed data. G.E.L. Y.L. and D.Z.C. contributed critical intellectual guidance to this study. I.H.G. S.M.G. and S.Z. wrote and revised the manuscript. S.Z. supervised the study. All authors reviewed the manuscript. The authors declare no competing interests. Funding Information: This work was funded by NIH R01 CA194697-01 and R01 CA222405-01A1 (S.Z.), Notre Dame CRND Catalyst Award (S.Z. and I.H.G.), NIH CTSI core facility pilot grants (S.Z.), and NSF CCF-1617735 (D.Z.C.). We would like to acknowledge and thank the Dee Family endowment (S.Z.). For insightful discussion and technical assistance, we thank Zhang Lab members, Vytas Bindokas, PhD, Samuel W. Brady, PhD, Kevin Brown, PhD, Andrea Gunawan, MS, Harikrishna Nakshatri, PhD, and Charles R. Tessier, PhD. We are grateful for the use of the following core facilities: Notre Dame Genomics and Bioinformatics Core Facility, Notre Dame Freimann Life Sciences Center, Harper Cancer Research Institute Biorepository, Indiana University School of Medicine South Bend Imaging and Flow Cytometry Core, University of Chicago Integrated Light Microscopy Facility, Indiana University Simon Cancer Center Core Facility, and Michigan State University Genomics Core. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
day = "25",
doi = "10.1016/j.cell.2020.09.064",
language = "English (US)",
volume = "183",
pages = "1234--1248.e25",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}