Closed-loop dynamic modeling of cerebral hemodynamics

V. Z. Marmarelis, D. C. Shin, M. E. Orme, R. Zhang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The dynamics of cerebral hemodynamics have been studied extensively because of their fundamental physiological and clinical importance. In particular, the dynamic processes of cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity have attracted broad attention because of their involvement in a host of pathologies and clinical conditions (e.g., hypertension, syncope, stroke, traumatic brain injury, vascular dementia, Alzheimer's disease, mild cognitive impairment etc.). This raises the prospect of useful diagnostic methods being developed on the basis of quantitative models of cerebral hemodynamics, if cerebral vascular dysfunction can be quantified reliably from data collected within practical clinical constraints. This paper presents a modeling method that utilizes beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity and end-tidal CO2 (collected non-invasively under resting conditions) to quantify the dynamics of CFA and cerebral vasomotor reactivity (CVMR). The unique and novel aspect of this dynamic model is that it is nonlinear and operates in a closed-loop configuration.

Original languageEnglish (US)
Pages (from-to)1029-1048
Number of pages20
JournalAnnals of biomedical engineering
Issue number5
StatePublished - May 2013


  • Cerebral autoregulation
  • Cerebral flow autoregulation
  • Cerebral vasomotor reactivity
  • Closed-loop modeling
  • Modeling cerebral hemodynamics
  • Nonlinear modeling

ASJC Scopus subject areas

  • Biomedical Engineering


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