CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes)

Dinesh Rakheja; Srinivas B. Narayan; Johanne V. Pastor; Michael J. Bennett

doi:10.1016/j.bbrc.2004.03.146

CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes)

Dinesh Rakheja, Srinivas B. Narayan, Johanne V. Pastor, Michael J. Bennett

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.

Original language	English (US)
Pages (from-to)	988-991
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	317
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2004.03.146
State	Published - May 14 2004

Keywords

CLN3
CLN3P
JNCL
Juvenile neuronal ceroid lipofuscinosis
Lipid rafts

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.03.146

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abstract = "Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.",

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AU - Rakheja, Dinesh

AU - Narayan, Srinivas B.

AU - Pastor, Johanne V.

AU - Bennett, Michael J.

PY - 2004/5/14

Y1 - 2004/5/14

N2 - Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.

AB - Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.

KW - CLN3

KW - CLN3P

KW - JNCL

KW - Juvenile neuronal ceroid lipofuscinosis

KW - Lipid rafts

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ER -

CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes)

Abstract

Keywords

ASJC Scopus subject areas

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