TY - JOUR
T1 - Clinicopathologic features of CD5-positive nodal marginal zone lymphoma
AU - Jaso, Jesse Manuel
AU - Yin, C. Cameron
AU - Wang, Sa A.
AU - Miranda, Roberto N.
AU - Jabcuga, Christine E.
AU - Chen, Lei
AU - Medeiros, L. Jeffrey
PY - 2013/11
Y1 - 2013/11
N2 - Objectives: To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL). Methods: We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL. Results: Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months). Conclusions: CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.
AB - Objectives: To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL). Methods: We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL. Results: Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months). Conclusions: CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.
KW - CD5
KW - Nodal marginal zone lymphoma
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U2 - 10.1309/AJCPEMVXES72DUIF
DO - 10.1309/AJCPEMVXES72DUIF
M3 - Article
C2 - 24124149
AN - SCOPUS:84886256457
SN - 0002-9173
VL - 140
SP - 693
EP - 700
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -