Clinical trials of peripheral stage I (TIN0M0) non-small cell lung cancer

Amit N. Patel, Ricardo S. Santos, Alberto De Hoyos, James D. Luketich, Rodney J. Landreneau

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Debate continues regarding the choice of resection for peripheral stage I (T1N0M0) non-small cell lung cancer (NSCLC). Anatomic lobectomy has been considered the standard of care for resectable NCSLC; however, intriguing results of clinical trials have been reported with the use of sublobar resection as primary therapy of selected small peripheral lung cancers. Most modern clinical studies comparing lobectomy to sublobar resection of stage I NSCLC demonstrate equivalent survival, but local recurrence following sublobar resection appears to be greater. Low energy coputed tomography screening programs for lung cancer have increasingly identified small peripheral lesions potentially amenable to effective therapeutic management with sublobar resection. We discuss the possible management scenarios for stage I NSCLC in this age of early computed tomography detection of lung cancer, more precise molecular biologic staging of the disease, optimized peri-operative management of the marginally resectable patient, and improved adjunctive treatment measures for local control following lung cancer resection.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalSeminars in thoracic and cardiovascular surgery
Issue number4
StatePublished - Oct 2003


  • Lung cancer
  • Lung resection

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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