Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method

Lisa Barker; Cindy Smith; Betsy Perkins; Karen Burhans; Rhonda Newman; Laurie Zimmerman; Jay Cook; Barry S. Russman; Frederick Samaha; Susan Iannaccone; C. Ralph Buncher; Michael White; Richard Browne

doi:10.1177/136140969200600402

Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method

Lisa Barker, Cindy Smith, Betsy Perkins, Karen Burhans, Rhonda Newman, Laurie Zimmerman, Jay Cook, Barry S. Russman, Frederick Samaha, Susan Iannaccone, C. Ralph Buncher, Michael White, Richard Browne

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We have developed a protocol to evaluate, prospectively, patients with spinal muscular atrophy (SMA) so that the natural course may be defined and treatment efficacy measured. A fixed myometry system with a sensitivity of 0.5 kgs. of force was used to eliminate the subjectivity experienced with manual muscle testing and handheld dynamometry. Thirteen patients were evaluated weekly for twelve weeks by the clinical evaluators (CEs). Intrarater reliability was established by demonstrating that repeated measurements by the same examiner were consistent. The CEs examined patients at each of the participating institutions on three separate occasions. Interrater reliability was demonstrated by showing that the strength evaluations made on the same subject by different evaluators did not differ significantly. The fixed myometry system was found to be a highly reliable method for evaluating very weak muscle groups in patients with SMA.

Original language	English (US)
Pages (from-to)	175-183
Number of pages	9
Journal	Neurorehabilitation and Neural Repair
Volume	6
Issue number	4
DOIs	https://doi.org/10.1177/136140969200600402
State	Published - Dec 1992

Keywords

Quantitative muscle strength assessment
Reliability
Spinal muscular atrophy

ASJC Scopus subject areas

Rehabilitation
Neurology
Clinical Neurology

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10.1177/136140969200600402

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Barker, L., Smith, C., Perkins, B., Burhans, K., Newman, R., Zimmerman, L., Cook, J., Russman, B. S., Samaha, F., Iannaccone, S., Buncher, C. R., White, M., & Browne, R. (1992). Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method. Neurorehabilitation and Neural Repair, 6(4), 175-183. https://doi.org/10.1177/136140969200600402

Barker, L, Smith, C, Perkins, B, Burhans, K, Newman, R, Zimmerman, L, Cook, J, Russman, BS, Samaha, F, Iannaccone, S, Buncher, CR, White, M & Browne, R 1992, 'Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method', Neurorehabilitation and Neural Repair, vol. 6, no. 4, pp. 175-183. https://doi.org/10.1177/136140969200600402

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abstract = "We have developed a protocol to evaluate, prospectively, patients with spinal muscular atrophy (SMA) so that the natural course may be defined and treatment efficacy measured. A fixed myometry system with a sensitivity of 0.5 kgs. of force was used to eliminate the subjectivity experienced with manual muscle testing and handheld dynamometry. Thirteen patients were evaluated weekly for twelve weeks by the clinical evaluators (CEs). Intrarater reliability was established by demonstrating that repeated measurements by the same examiner were consistent. The CEs examined patients at each of the participating institutions on three separate occasions. Interrater reliability was demonstrated by showing that the strength evaluations made on the same subject by different evaluators did not differ significantly. The fixed myometry system was found to be a highly reliable method for evaluating very weak muscle groups in patients with SMA.",

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author = "Lisa Barker and Cindy Smith and Betsy Perkins and Karen Burhans and Rhonda Newman and Laurie Zimmerman and Jay Cook and Russman, {Barry S.} and Frederick Samaha and Susan Iannaccone and Buncher, {C. Ralph} and Michael White and Richard Browne",

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AU - Newman, Rhonda

AU - Zimmerman, Laurie

AU - Cook, Jay

AU - Russman, Barry S.

AU - Samaha, Frederick

AU - Iannaccone, Susan

AU - Buncher, C. Ralph

AU - White, Michael

AU - Browne, Richard

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Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method

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