Clinical research in primary stroke prevention: Needs, opportunities, and challenges

Barbara Radziszewska; Robert G. Hart; Philip A. Wolf; Ralph B. D'Agostino; Jeffrey A. Cutler; Joseph P. Broderick; Bruce M. Coull; Mary Cushman; Ralph B. D'Agostino; Donald J. Easton; Paula Einhorn; Larry B. Goldstein; Philip B. Gorelick; Steven Haffner; George Howard; S. Claiborne Johnston; Walter Kernan; Will Longstreth; Dilip K. Pandey; Joseph F. Polak; Ralph L. Sacco; Daniel E. Singer; James Toole; Steven J. Warach

doi:10.1159/000086342

Clinical research in primary stroke prevention: Needs, opportunities, and challenges

Barbara Radziszewska, Robert G. Hart, Philip A. Wolf, Ralph B. D'Agostino, Jeffrey A. Cutler, Joseph P. Broderick, Bruce M. Coull, Mary Cushman, Ralph B. D'Agostino, Donald J. Easton, Paula Einhorn, Larry B. Goldstein, Philip B. Gorelick, Steven Haffner, George Howard, S. Claiborne Johnston, Walter Kernan, Will Longstreth, Dilip K. Pandey, Joseph F. PolakRalph L. Sacco, Daniel E. Singer, James Toole, Steven J. Warach

Neurology & Neurotherapeutics

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Most (∼70%) of strokes are first-ever strokes, and hence to substantially reduce the neurological burden, primary prevention is crucial. Here, highlights of the National Institute of Neurological Disorders and Stroke workshop 'Stroke Risk Assessment and Future Stroke Primary Prevention Trials' held January 12-13, 2004 are summarized. The Workshop discussions focused on stroke risk assessment; the high-risk vs. population-based approaches to primary prevention; desirable characteristics of candidate treatments and potential novel treatments, such as the 'polypill'; subclinical disease as risk assessment tool and as surrogate outcome, and methodological issues in stroke primary prevention trials. The importance of assessing cognitive decline as an important consequence of covert and overt vascular injury of the brain was emphasized. The scientific or logistic barriers to stroke primary prevention trials are challenging, but are not insurmountable.

Original language	English (US)
Pages (from-to)	91-104
Number of pages	14
Journal	Neuroepidemiology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1159/000086342
State	Published - Aug 1 2005

Keywords

Clinical trial
Primary prevention
Risk factors
Stroke prevention

ASJC Scopus subject areas

Epidemiology
Clinical Neurology

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10.1159/000086342

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Radziszewska, B., Hart, R. G., Wolf, P. A., D'Agostino, R. B., Cutler, J. A., Broderick, J. P., Coull, B. M., Cushman, M., D'Agostino, R. B., Easton, D. J., Einhorn, P., Goldstein, L. B., Gorelick, P. B., Haffner, S., Howard, G., Johnston, S. C., Kernan, W., Longstreth, W., Pandey, D. K., ... Warach, S. J. (2005). Clinical research in primary stroke prevention: Needs, opportunities, and challenges. Neuroepidemiology, 25(2), 91-104. https://doi.org/10.1159/000086342

Radziszewska, B, Hart, RG, Wolf, PA, D'Agostino, RB, Cutler, JA, Broderick, JP, Coull, BM, Cushman, M, D'Agostino, RB, Easton, DJ, Einhorn, P, Goldstein, LB, Gorelick, PB, Haffner, S, Howard, G, Johnston, SC, Kernan, W, Longstreth, W, Pandey, DK, Polak, JF, Sacco, RL, Singer, DE, Toole, J & Warach, SJ 2005, 'Clinical research in primary stroke prevention: Needs, opportunities, and challenges', Neuroepidemiology, vol. 25, no. 2, pp. 91-104. https://doi.org/10.1159/000086342

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AB - Most (∼70%) of strokes are first-ever strokes, and hence to substantially reduce the neurological burden, primary prevention is crucial. Here, highlights of the National Institute of Neurological Disorders and Stroke workshop 'Stroke Risk Assessment and Future Stroke Primary Prevention Trials' held January 12-13, 2004 are summarized. The Workshop discussions focused on stroke risk assessment; the high-risk vs. population-based approaches to primary prevention; desirable characteristics of candidate treatments and potential novel treatments, such as the 'polypill'; subclinical disease as risk assessment tool and as surrogate outcome, and methodological issues in stroke primary prevention trials. The importance of assessing cognitive decline as an important consequence of covert and overt vascular injury of the brain was emphasized. The scientific or logistic barriers to stroke primary prevention trials are challenging, but are not insurmountable.

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Clinical research in primary stroke prevention: Needs, opportunities, and challenges

Abstract

Keywords

ASJC Scopus subject areas

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