Abstract
The pharmacokinetic properties of methicillin were investigated in 59 newborn infants. Concentrations of methicillin in serum were approximately 58 and 80 μg/ml at one hour after 25 and 50 mg/kg doses, respectively. The average serum half-life values ranged from one to three hours and were inversely correlated with birth weight and chronologic age. The half-life values, volumes of distribution, and plasma clearances of methicillin are shown in relationship to gestational age and chronologic age. A dosage of 25 mg/kg is recommended for therapy of most neonatal staphylococcal diseases; the frequency of administration is altered on the basis of birth weight and chronologic age.
Original language | English (US) |
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Pages (from-to) | 1005-1008 |
Number of pages | 4 |
Journal | The Journal of pediatrics |
Volume | 90 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1977 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health