Clinical pharmacology of methicillin in neonates

Larrie D. Sarff, George H. McCracken, Marion L. Thomas, Linda J. Horton, Norma Threlkeld

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The pharmacokinetic properties of methicillin were investigated in 59 newborn infants. Concentrations of methicillin in serum were approximately 58 and 80 μg/ml at one hour after 25 and 50 mg/kg doses, respectively. The average serum half-life values ranged from one to three hours and were inversely correlated with birth weight and chronologic age. The half-life values, volumes of distribution, and plasma clearances of methicillin are shown in relationship to gestational age and chronologic age. A dosage of 25 mg/kg is recommended for therapy of most neonatal staphylococcal diseases; the frequency of administration is altered on the basis of birth weight and chronologic age.

Original languageEnglish (US)
Pages (from-to)1005-1008
Number of pages4
JournalThe Journal of pediatrics
Issue number6
StatePublished - Jun 1977

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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