TY - JOUR
T1 - Clinical Outcomes in Sebaceous Carcinoma
T2 - A Retrospective Two-Center Cohort Study
AU - Kibbi, Nour
AU - Petric, Ursa B.
AU - El-Banna, Ghida
AU - Beaulieu, Derek M.
AU - Rajan, Neil
AU - Srivastava, Divya
AU - Aasi, Sumaira Z.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - BACKGROUNDSebaceous carcinoma (SC) is a rare, potentially recurrent, and life-threatening cutaneous malignancy that can be associated with Muir-Torre syndrome (MTS), a DNA mismatch repair-driven genodermatosis. Earlier studies examining factors associated with recurrence have focused on periocular tumors only.OBJECTIVEExamine outcomes of SC and identify factors associated with recurrence.MATERIALS AND METHODSRetrospective study from 2 tertiary care centers.RESULTSSixty-seven cases from 63 patients were identified, including 7 cases of MTS and 13 arising in the context of immunosuppression. Fifty-five cases (82.1%) were treated with complete circumferential peripheral and deep margin assessment (CCPDMA) methods. Five recurrences developed during the postoperative period. On univariate analysis, periocular location (odds ratio [OR] 7.6, p =.0410), and lesion size ≥2 cm (OR 9.6, p =.005) were associated with recurrence, whereas CCPDMA (OR 0.052, p =.0006) was inversely associated with recurrence. On multivariate analysis, only lesion size ≥2 cm (OR 9.6, p =.0233) and CCPDMA approaches (OR 0.052, p =.007) were significant.CONCLUSIONNon-complete circumferential peripheral and deep margin assessment methods and large lesion size were independent risk factors predicting recurrence, whereas anatomic subtype and MTS status were not. These findings can assist in identifying SC cases that may benefit from more aggressive treatment and closer surveillance.
AB - BACKGROUNDSebaceous carcinoma (SC) is a rare, potentially recurrent, and life-threatening cutaneous malignancy that can be associated with Muir-Torre syndrome (MTS), a DNA mismatch repair-driven genodermatosis. Earlier studies examining factors associated with recurrence have focused on periocular tumors only.OBJECTIVEExamine outcomes of SC and identify factors associated with recurrence.MATERIALS AND METHODSRetrospective study from 2 tertiary care centers.RESULTSSixty-seven cases from 63 patients were identified, including 7 cases of MTS and 13 arising in the context of immunosuppression. Fifty-five cases (82.1%) were treated with complete circumferential peripheral and deep margin assessment (CCPDMA) methods. Five recurrences developed during the postoperative period. On univariate analysis, periocular location (odds ratio [OR] 7.6, p =.0410), and lesion size ≥2 cm (OR 9.6, p =.005) were associated with recurrence, whereas CCPDMA (OR 0.052, p =.0006) was inversely associated with recurrence. On multivariate analysis, only lesion size ≥2 cm (OR 9.6, p =.0233) and CCPDMA approaches (OR 0.052, p =.007) were significant.CONCLUSIONNon-complete circumferential peripheral and deep margin assessment methods and large lesion size were independent risk factors predicting recurrence, whereas anatomic subtype and MTS status were not. These findings can assist in identifying SC cases that may benefit from more aggressive treatment and closer surveillance.
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U2 - 10.1097/DSS.0000000000004016
DO - 10.1097/DSS.0000000000004016
M3 - Article
C2 - 37962979
AN - SCOPUS:85178494670
SN - 1076-0512
VL - 49
SP - 1122
EP - 1127
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 12
ER -