TY - JOUR
T1 - Clinical features of mesotherapy-Associated non-Tuberculous mycobacterial infections
T2 - A systematic review
AU - Singsing, Melissa E.
AU - Duncan, Steven G.
AU - Vachon, M. Jonathan
AU - Goff, Heather W.
N1 - Publisher Copyright:
© 2022 The Authors.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Background: Cutaneous infections from non-Tuberculous mycobacteria (NTM) are a well-documented but poorly characterized adverse event following mesotherapy injections. Objective: This study aims to consolidate the available literature to characterize demographic and clinical features of mesotherapyassociated NTM infections. Methods: Using PRISMA guidelines, a systematic review of PubMed, Scopus, and Embase databases was undertaken for articles reporting cases of NTM skin infections following mesotherapy. Data were analyzed using Microsoft Excel. Results: Of 1966 search results, 30 articles (N = 423 patients) met inclusion criteria. Studies were largely from South America, and patients were mostly women aged 16-55 with NTM infections arising in the abdomen, buttocks, or thighs. Nearly all patients developed multiple, well-localized lesions without systemic symptoms. Effect summary by meta-Analysis revealed most infections resolved after antibiotic therapy, though many patients required multiple antibiotic courses and/or agents to resolve infection. Infections often took weeks to resolve and were complicated by post-Treatment scarring. Limitations: The main limitation of this study was the heterogeneity and lack of consistency between case reports. Conclusion: Cutaneous NTM infections associated with mesotherapy generally occur in women of childbearing age, arise from injections contaminated by the environment, and are often complicated by scarring/poor cosmesis and prolonged treatment course.
AB - Background: Cutaneous infections from non-Tuberculous mycobacteria (NTM) are a well-documented but poorly characterized adverse event following mesotherapy injections. Objective: This study aims to consolidate the available literature to characterize demographic and clinical features of mesotherapyassociated NTM infections. Methods: Using PRISMA guidelines, a systematic review of PubMed, Scopus, and Embase databases was undertaken for articles reporting cases of NTM skin infections following mesotherapy. Data were analyzed using Microsoft Excel. Results: Of 1966 search results, 30 articles (N = 423 patients) met inclusion criteria. Studies were largely from South America, and patients were mostly women aged 16-55 with NTM infections arising in the abdomen, buttocks, or thighs. Nearly all patients developed multiple, well-localized lesions without systemic symptoms. Effect summary by meta-Analysis revealed most infections resolved after antibiotic therapy, though many patients required multiple antibiotic courses and/or agents to resolve infection. Infections often took weeks to resolve and were complicated by post-Treatment scarring. Limitations: The main limitation of this study was the heterogeneity and lack of consistency between case reports. Conclusion: Cutaneous NTM infections associated with mesotherapy generally occur in women of childbearing age, arise from injections contaminated by the environment, and are often complicated by scarring/poor cosmesis and prolonged treatment course.
KW - Cutaneous infection
KW - Injections
KW - Mesotherapy
KW - Non-Tuberculous mycobacteria
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U2 - 10.1097/JW9.0000000000000059
DO - 10.1097/JW9.0000000000000059
M3 - Article
AN - SCOPUS:85168597725
SN - 2352-6475
VL - 8
JO - International Journal of Women's Dermatology
JF - International Journal of Women's Dermatology
IS - 4
M1 - A53
ER -