Cisplatin-induced renal salt wasting syndrome

Tamim Hamdi, Shadi Latta, Bassel Jallad, Fayez Kheir, Mohamad N. Alhosaini, Ashok Patel

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Cisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal impairment with a decline in glomerular filtration has been the classical nephrotoxicity of cisplatin. Renal salt wasting syndrome is yet another, though it is not common. Previous studies were identified by searching the Pubmed database using the following keywords: cisplatin, cisplatin nephrotoxicity, renal salt wasting, and salt loosing nephropathy. Renal salt wasting syndrome has been described in 17 case reports since 1984. It is a rare side effect of cisplatin that manifests with polyuria, hypovolemia, and hyponatremia, and, because of similarities in clinical settings and laboratory values, it is frequently misdiagnosed as a syndrome of inappropriate antidiuretic hormone. Other causes of polyuria and hyponatremia should be excluded. Treatment aims at restoring the lost water and salt. Substituting cisplatin with carboplatin depends on individual clinical settings. Prognosis is excellent, as recovery was the rule in all the reported cases.

Original languageEnglish (US)
Pages (from-to)793-799
Number of pages7
JournalSouthern medical journal
Issue number8
StatePublished - Aug 1 2010


  • cisplatin
  • renal salt wasting syndrome
  • salt and water replacement
  • sodium balance
  • syndrome of inappropriate antidiuretic hormone

ASJC Scopus subject areas

  • Medicine(all)


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