Cirrhosis and trauma are a lethal combination

Chrysanthos Georgiou, Kenji Inaba, Pedro G R Teixeira, Pantelis Hadjizacharia, Linda S. Chan, Carlos Brown, Ali Salim, Peter Rhee, Demetrios Demetriades

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Background: The objective of this study was to evaluate the risk of mortality and complications associated with cirrhosis in trauma patients. Methods: This is an IRB-approved retrospective trauma registry study of patients admitted to an academic level 1 trauma center from 1997 to 2006. The following parameters were abstracted for analysis: age, gender, mechanism of injury, Abbreviated Injury Score, Injury Severity Score, Glasgow Coma Scale, mortality, and complications (ARDS, acute renal failure, pneumonia, intra-abdominal abscess, trauma-associated coagulopathy). Multivariable analysis was utilized to compare the mortality and complication rates between cirrhotic and noncirrhotic trauma patients. The subgroup of patients who underwent laparotomy was also analyzed. Results: During the 10-year study period there were 36,038 trauma registry patients, of which 468 (1.3%) had a diagnosis of cirrhosis. The mortality in the cirrhotic group was 12% vs. 6% in the noncirrhotic group [adjusted odds ratio = 5.65 (95% CI = 3.72 - 8.41, p < 0.0001)]. ARDS, trauma-associated coagulopathy, and septic complications were significantly more common in the cirrhotic group. The overall severe complication rate in the two groups was 10 and 4%, respectively [adjusted odds ratio = 2.05 (95% CI = 1.45 - 2.84, p < 0.0001)]. For the subgroup of patients who underwent emergent abdominal exploration, the mortality rate increased to 40% compared with that of noncirrhotics at 15% [adjusted odds ratio = 4.35 (95% CI = 2.00 - 9.18, p = 0.0002)]. Conclusion: Cirrhosis is an independent risk factor for increased mortality and higher complication rate following trauma. Injured patients who undergo laparotomy are significantly more likely to die than noncirrhotic patients. Injured patients with cirrhosis warrant aggressive monitoring and treatment.

Original languageEnglish (US)
Pages (from-to)1087-1092
Number of pages6
JournalWorld Journal of Surgery
Issue number5
StatePublished - May 1 2009

ASJC Scopus subject areas

  • Surgery


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