Circadian rhythms: Molecular basis of the clock

Lisa D. Wilsbacher, Joseph S. Takahashi

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Much progress has been made during the past year in the molecular dissection of the circadian clock. Recently identified circadian genes in mouse, Drosophila, and cyanobacteria demonstrate the universal nature of negative feedback regulation as a circadian mechanism; furthermore, the mouse and Drosophila genes are structurally and functionally conserved. In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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