TY - JOUR
T1 - Chromosomal localization of the human retinoid x receptors
AU - Almasan, Alexandru
AU - Mangelsdorf, David J.
AU - Ong, Estelita S.
AU - Wahl, Geoffrey M.
AU - Evans, Ronald M.
PY - 1994/4
Y1 - 1994/4
N2 - The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, we report high-resolution localization of the human RXR genes within cytogenetic bands and also within a standard reference map of cosmid DNA markers on human chromosomes. We have determined the location of the human RXR genes by pairwise hybridization of the RXR cosmids and reference markers, using fluorescence in situ hybridization. We localized (i) RXRα (RXRA) to chromosome 9 band q34.3; (ii) RXRβ (RXRB) to chromosome 6 band 21.3; and (iii) RXRγ (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive transcription factors have been identified so far, including three retinoic acid receptors in addition to the three RXRs. Interestingly, each of these receptors in human and mouse is encoded by genes located at distinct chromosomal loci and on separate chromosomes. The proximity of RXR genes to loci known to be associated with genetic disorders suggests that their location may be useful in establishing a link between RXRs and certain human diseases.
AB - The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, we report high-resolution localization of the human RXR genes within cytogenetic bands and also within a standard reference map of cosmid DNA markers on human chromosomes. We have determined the location of the human RXR genes by pairwise hybridization of the RXR cosmids and reference markers, using fluorescence in situ hybridization. We localized (i) RXRα (RXRA) to chromosome 9 band q34.3; (ii) RXRβ (RXRB) to chromosome 6 band 21.3; and (iii) RXRγ (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive transcription factors have been identified so far, including three retinoic acid receptors in addition to the three RXRs. Interestingly, each of these receptors in human and mouse is encoded by genes located at distinct chromosomal loci and on separate chromosomes. The proximity of RXR genes to loci known to be associated with genetic disorders suggests that their location may be useful in establishing a link between RXRs and certain human diseases.
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U2 - 10.1006/geno.1994.1193
DO - 10.1006/geno.1994.1193
M3 - Article
C2 - 8034312
AN - SCOPUS:0028344597
SN - 0888-7543
VL - 20
SP - 397
EP - 403
JO - Genomics
JF - Genomics
IS - 3
ER -